Glucose-Level During Endurance Exercise

NCT07543705 | Not Yet Recruiting

• 1 other identifier: 276/25
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

As part of the mandatory annual assessment of physical fitness, soldiers are required to complete a standardized military march. A total of 100 healthy volunteer participants will be recruited from soldiers serving at the Bundeswehr Hospital Ulm. During this march, physiological and metabolic parameters will be assessed. At baseline, anthropometric data and information on medical history, lifestyle, and fitness status will be collected, including a validated questionnaire on physical activity. Blood and urine samples will be obtained to determine routine laboratory and metabolic parameters, and body composition will be assessed using bioelectrical impedance analysis. In addition, selected sensors will be applied to continuously record physiological data. Participants will then complete a 6 km march carrying 15 kg of equipment. After completion of the march, sensors will be removed and additional blood and urine samples will be collected to evaluate metabolic responses to physical exertion, including catecholamine levels.

Conditions

Glucose Metabolism

Keywords

glucose levels; endurance exercise; continuous glucose monitoring

Outcome Measures

Primary Outcomes (5)

• Glucose dynamics during exercise

  Interstitial glucose responses during the standardized endurance exercise (6 kilometer march with 15 kilogram load) measured via continuous glucose monitoring.

  1 hour

• Sympathetic nervous system activation (catecholamines)

  Activation of the sympathetic nervous system during a standardized endurance exercise measured via changes in catecholamine levels.

  Baseline, immediately after the march (approximately 1 hour after baseline)

• Correlation between sympathetic activation (catecholamines) and glucose dynamics during endurance exercise

  Correlation between sympathetic nervous system activation measured via catecholamine levels and glucose responses during a standardized endurance exercise (6 kilometer march with 15 kilogram load).

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

• Heart rate variability

  Heat rate variability during a standardized endurance exercise measured via electrocardiography.

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

• Correlation between heart rate variability and glucose dynamics during endurance exercise

  Correlation between heart rate variability and glucose responses during a standardized endurance exercise (6 kilometer march with 15 kilogram load).

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

Secondary Outcomes (10)

• Training status

  Baseline

• Correlation between training status and glucose dynamics during endurance exercise

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

• Body composition

  Baseline.

• Correlation between body composition and glucose dynamics during exercise.

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

• Biomarkers of inflammatory response

  Baseline and immediately after the march (approximately 1 hour after baseline)

Other Outcomes (7)

• Sex differences in correlation between sympathetic activation (catecholamines) and glucose dynamics during endurance exercise

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

• Sex differences in the correlation between heart rate variability and glucose dynamics during endurance exercise

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

• Sex differences in the correlation of training status with glucose dynamics during endurance exercise

  Baseline, during the 1 hour-march, immediately after the march (approximately 1 hour after baseline)

Study Arms (1)

Soldiers

healthy volunteer participants recruited from soldiers serving at the Bundeswehr Hospital Ulm

Other: Standardized military march

Interventions

Standardized military march OTHER

6 km march carrying 15 kg of equipment. The march will be conducted in uniform in accordance with central military regulations. Participants will be equipped with a continuous glucose monitor an electrocardiography wearable during the march. Before and after the march blood and urine samples will be obtained.

Soldiers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

healthy volunteer participants recruited from soldiers serving at the Bundeswehr Hospital Ulm

You may qualify if:

• BMI between 18.5 and 30 kg/m\^2

You may not qualify if:

• Pregnancy or lactation
• cardiovascular disease
• vegan diet
• drug or alcohol abuse
• Drug therapy that raises or lowers blood sugar, e.g. steroids, antidiabetics, insulin or influences the autonomic nervous system
• No consent to be informed about incidentally discovered pathological findings
• Any other (clinical) condition that would endanger participants safety or question scientific success according to the physicians opinion.

Sponsors & Collaborators

• University of Ulm: lead

Study Sites (1)

Bundeswehr Hospital Ulm

Ulm, 89081, Germany

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood and urine samples

Study Officials

• Martin Heni, MD

  University of Ulm

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Martin Heni, MD

CONTACT

+4973150044505; martin.heni@uniklinik-ulm.de

Sabrina Wanglelr

CONTACT

+4973150044782; sabrina.wangler@uniklinik-ulm.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Section Endocrinology and Diabetology, Full Professorship (W3) for Endocrinology and Diabetology

Study Record Dates

• First Submitted: March 16, 2026
• First Posted: April 22, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): June 1, 2028
• Last Updated: April 22, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)