Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis

NCT07542652 | Recruiting

• 1 other identifier: KY20262104-F-1
• Study Type: observational
• Target: 450
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this clinical trial is to explore the correlation between the level of microplastic exposure and the risk of gastric mucosal carcinogenesis, and to evaluate the strength of its effect as an independent risk factor. The main questions it aims to answer include: Does the level of microplastic exposure increase the risk of gastric mucosal carcinogenesis? Can the correlation between the level of microplastic exposure and gastric mucosal carcinogenesis, as well as the sources of high - risk microplastic exposure, be explored through a questionnaire on external microplastic exposure? Researchers will complete a design structured questionnaire and ask participants to fill it out carefully and truthfully to determine whether the level of microplastic exposure increases the risk of gastric mucosal carcinogenesis.

Conditions

Gastric Carcinoma; Gastritis Chronic; Intestinal Metaplasia; Gastric Precancerous Lesions

Outcome Measures

Primary Outcomes (1)

• Correlation between external exposure levels of microplastics and three pathological stages of gastric mucosal carcinogenesis

  The investigators evaluated the correlation between external exposure to microplastics and the three pathological stages of gastric mucosal carcinogenesis based on the patients' final diagnosis results and the completed questionnaires they filled out.

  9 months

Secondary Outcomes (2)

• Analysis of sources of high - risk microplastic exposure

  9 months

• Synergistic toxicity of microplastics and Helicobacter pylori

  9 months

Study Arms (3)

Chronic non-atrophic gastritis

Patients diagnosed with chronic non-atrophic gastritis based on endoscopic and/or histopathological results

precancerous lesion

Patients with chronic atrophic gastritis, gastric intestinal metaplasia, and gastric intraepithelial neoplasia based on endoscopic and/or histopathological results

gastric cancer

patients with gastric cancer according to endoscopic and/or histopathological results

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients were enrolled from a single center, Xijing Hospital.

You may qualify if:

• Aged between 18 and 75 years old, gender is not restricted
• Having a clear diagnosis result within the recent three months and being diagnosed with chronic non - atrophic gastritis, precancerous lesions of gastric cancer, or gastric cancer for the first time
• Have clear Helicobacter pylori (Hp) test results
• Be in normal mental state and able to independently complete the questionnaire survey

You may not qualify if:

• Patients with a history of malignant tumors in other parts
• Patients who have previously undergone upper gastrointestinal surgery, chemotherapy, or radiotherapy
• Patients with severe diseases of major organs such as the heart, lungs liver, and kidneys
• Patients who are currently receiving psychological intervention or taking psychiatric drugs
• Pregnant or lactating women
• Patients with severe missing clinical data or questionnaire information
• Refusing to sign the informed consent form

Sponsors & Collaborators

• Yongquan Shi: lead

Study Sites (1)

Xijing Hosipital of Digestive Disease

Xi'an, Shaanxi, 710032, China

RECRUITING

MeSH Terms

Conditions

Stomach Neoplasms

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases

Central Study Contacts

Yongquan Shi

CONTACT

029-84771515; shiyquan@fmmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 14, 2026
• First Posted: April 21, 2026
• Study Start: March 31, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 30, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)