Exploration of Lymph Node Metastasis and Tumor Deposit in the Posterior Gastric Mesentery for Distal Gastric Cancer

NCT06736847 | Recruiting DMC

• 1 other identifier: 2024-0899
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate lymph node metastasis and tumor deposit in the posterior gastric mesentery following distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer.

Conditions

Gastric Carcinoma

Keywords

Gastric cancer; Lymph node dissection; Posterior gastric mesentery; Lymph node metastasis

Outcome Measures

Primary Outcomes (1)

• Rate of lymph node metastasis and tumor deposit in the posterior gastric mesentery

  through study completion, an average of 1 year

Study Arms (1)

Radical gastrectomy with membrane dissection

Procedure: distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer

Interventions

distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer PROCEDURE

distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer

Radical gastrectomy with membrane dissection

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who met the above inclusion and exclusion criteria

You may qualify if:

• Aged older than 18 years and younger than 85 years
• Primary gastric adenocarcinoma confirmed by preoperative pathology result
• cT2-4N0-3M0 at preoperative evaluation according to the American Joint 8 Committee on Cancer (AJCC) Cancer Staging Manual 7th Edition
• Patients who received distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision
• American Society of Anesthesiologists (ASA) class I, II, or III
• Written informed consent

You may not qualify if:

• Negative preoperative biopsy
• Too late tumour stage or metastasis (cT4b/M1)
• BMI\>30 kg/m2
• Total gastrectomy or proximal gastrectomy
• previous neoadjuvant chemotherapy or radiotherapy
• Previous upper abdominal surgery
• Combined with other malignant diseases
• Reject operation

Sponsors & Collaborators

• Jichao Qin: lead

Study Sites (1)

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310000, China

RECRUITING

MeSH Terms

Conditions

Stomach Neoplasms; Lymphatic Metastasis

Interventions

Gastroenterostomy

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Neoplasm Metastasis; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anastomosis, Surgical; Surgical Procedures, Operative; Digestive System Surgical Procedures

Central Study Contacts

Tao Wang, Ph.d

CONTACT

+86-197-068-25286; 15002740874@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: September 1, 2024
• First Posted: December 17, 2024
• Study Start: May 1, 2024
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: September 2, 2025

Record last verified: 2025-08

Locations

CN (1)