Trials Sponsors Conditions Drugs Pricing

Conditions

Autologous Transplantation Azoospermia or Severe Oligozoospermia Infertility

Keywords

autotransplantation of immature testicular tissuefertility preservationprepubertal boyscryopreserved testicular tissueprepubertal testicular tissue

Outcome Measures

Primary Outcomes (1)

Assessment of graft function
Blood sampling for hormones and growth of the graft as visulalized by ultrasound will be performed during follow-up. Presence of sperm will be evaluated at the recovery of the graft.
Assessments of hormones and growth of the graft will be performed at 1 month (M), 3 M, 6M, 12M, 24 M after grafting/transplantation procedure. Presence of sperm will be performed at graft recovery (immediately during surgery on fresh and fixed samples).

Secondary Outcomes (1)

Assesment of conception potential of sperm recovered in grafts and used in ART
HCGb in blood at Day 15 (+-1 Day) post-ICSI and if positive confirmed after 48 Hours (+-24 Hours). Ultrasound 15 Days +-7 Days after ICSI.

Study Arms (1)

Autologous transplantation of cryopreserved immature testicular tissue in azoospermic adults

EXPERIMENTAL

Avascular transplantation of own testicular tissue pieces cryopreserved during childhood will be performed during a surgical sperm retrieval procedure when no sperm is found.

Procedure: autologous transplantation of cryopreserved testicular tissue

Interventions

autologous transplantation of cryopreserved testicular tissueProcedure

Avascular autologous transplantation of frozen-thawed immature testicular tissue pieces will be performed in azoospermic adult patients during a surgical sperm retrieval procedure if no sperm is found peroperatively.

Also known as: testicular tissue autografting

Autologous transplantation of cryopreserved immature testicular tissue in azoospermic adults

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 40 Years

Sexmale(Gender-based eligibility)

Gender Eligibility DetailsMale adult survivors of a childhood cancer who cryopreserved their tissue for own use as a fertility preservation method are eligible.

Healthy VolunteersNo

Age GroupsAdult (18-64)

You may qualify if:

patients who have completed their gonadotoxic treatment

Sponsors & Collaborators

Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Otherlead

Study Sites (1)

Cliniques universitaires Saint-Luc, Université catholique de Louvain

Brussels, 1200, Belgium

RECRUITING

Patricia Van Aken, Study nurseCONTACT003227647803 patricia.vanaken@saintluc.uclouvain.be

CONTACTchristine.wyns@saintluc.uclouvain.be

Christine Wyns, MD, PhDPRINCIPAL INVESTIGATOR

Marc Kanbar, MD, PhDSUB INVESTIGATOR

MeSH Terms

Conditions

AzoospermiaOligospermiaInfertility

Condition Hierarchy (Ancestors)

Infertility, MaleGenital Diseases, MaleGenital DiseasesUrogenital DiseasesMale Urogenital Diseases

Study Officials

Christine Wyns, MD, PhD
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
PRINCIPAL INVESTIGATOR

Central Study Contacts

Christine Wyns, MD, PhD, Full Professor

CONTACT

003227641101 christine.wyns@saintluc.uclouvain.be

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

March 20, 2026

First Posted

April 21, 2026

Study Start

November 19, 2025

Actual (reported)

Primary Completion

November 2035

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (1)

Autologous transplantation of cryopreserved immature testicular tissue in azoospermic adults

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (1)

Autologous transplantation of cryopreserved immature testicular tissue in azoospermic adults

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations