The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity

NCT07542327 | Not Yet Recruiting

• 1 other identifier: 26/14976
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to explore if GPCR-autoantibodies:

1. 1.are pressent in people living with obesity, and are associated with degree of obesity
2. 2.if it is associated with obesity related diseases

Conditions

Obesity; Obesity & Overweight; Obesity Type 2 Diabetes Mellitus; Obesity and Obesity-related Medical Conditions

Keywords

Obesity; obesity-related medical conditions; GPCR- autoantibodies

Outcome Measures

Primary Outcomes (1)

• Exploring the pressence and role of GPCR-autoantibodies in obesity

  explore the pressence of GPCR-autoantibodies in people living with obesity, and if there is any association with the degree of obesity

  At the time of enrolement

Secondary Outcomes (1)

• Exploring the association between GPCR-autoantibodies and obesity related diseases

  At the time of enrolment

Study Arms (1)

The South Danish Obesity Initiative (SDOI)

The project will take advantage of the South Danish Obesity Initiative (SDOI) cohort. This is an ongoing clinical initiative, offering screening of a broad panel of obesity related diseases to individuals with BMI above 30 kg/m² and age between 18 and 60 years. People are referred from their general practitioners or from hospital departments and undergo screening for diabetes, dyslipidemia, obstructive sleep apnea, metabolic-associated steatohepatitis and hypertension. In addition, the participants answer questionnaires. A cohort of people with BMI 18.5 to 30 kg/m² has been assessed with an identical screening program with the purpose of serving as a control group. Only participants who gave informed consent to use their data for research purposes are included in this study. The study protocol and initial results have previously been published (Juhl C.B, et al 2024.DOI: 10.2147/DMSO.S456028).

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The South Danish Obesity Initiative (SDOI) cohort. This is an ongoing clinical initiative offering screening of a broad panel of obesity related diseases to individuals with BMI above 30 kg/m² and age between 18 and 60 years. People are referred from their general practitioners or from hospital departments and undergo screening for diabetes, dyslipidemia, obstructive sleep apnea, metabolic associated steatohepatitis and hypertension. In addition, a cohort of people with BMI 18.5 to 30 kg/m² has been assessed with an identical screening program with the purpose of serving as a control group. Only participants who gave informed consent to use their data for research purposes are included in this study.

You may qualify if:

• Inhabitant in the Region of Southern Denmark
• BMI above 30kg/m2
• age between 18 and 60 years.

You may not qualify if:

• individuals previously treated with GLP-1RA medication for any indication
• Individuals who have previously undergone bariatric surgery
• Individuals with type 1 diabetes

Sponsors & Collaborators

• Claus Bogh Juhl: lead

Study Sites (1)

University Hospital of Southern Denmark, Esbjerg

Esbjerg, Region Syddanmark, 6700, Denmark

Location

Biospecimen

Retention: SAMPLES WITH DNA

blood and blood serum samples

MeSH Terms

Conditions

Obesity; Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Claus B Juhl, Professor, MD, PhD

  University Hospital of Southern Denmark, Esbjerg

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tobias M Windedal, MD

CONTACT

42957945; tobias.midtvedt.windedal@rsyd.dk

Claus B Juhl, Professor, MD, PhD

CONTACT

79183120; claus.bogh.juhl@rsyd.dk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor, MD, PhD.

Study Record Dates

• First Submitted: April 14, 2026
• First Posted: April 21, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: April 24, 2026

Record last verified: 2026-04

Locations

DK (1)