Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow

NCT07540481 | Not Yet Recruiting

• 1 other identifier: IJVC
• Study Type: observational
• Target: 61
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia. ONSD will be measured noninvasively using transorbital ultrasonography, and carotid Doppler parameters will be assessed at two time points: after endotracheal intubation and approximately 5 minutes after catheterization. The primary objective is to assess short-term changes in ONSD following catheterization. Secondary objectives include evaluating changes in carotid Doppler measurements and their relationship with ONSD, as well as associations with physiological parameters such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.

Conditions

Intracranial Pressure; Ultrasonography

Keywords

Internal Jugular Vein; Catheterization; Ultrasonography; Optic Nerve Sheath Diameter; Intracranial Pressure; General Anesthesia

Outcome Measures

Primary Outcomes (1)

• Change in Optic Nerve Sheath Diameter (mm) Following Internal Jugular Vein Catheterization

  Optic nerve sheath diameter (ONSD) will be measured in millimeters using transorbital ultrasonography at 3 mm posterior to the optic disc on the side of catheterization. The outcome is defined as the difference between measurements obtained immediately after endotracheal intubation (baseline) and 5 minutes after internal jugular vein catheterization. Higher values indicate increased optic nerve sheath diameter.

  Baseline (immediately after endotracheal intubation) and 5 minutes after internal jugular vein catheterization

Secondary Outcomes (8)

• Change in Internal Carotid Artery Peak Systolic Velocity (PSV) Following Internal Jugular Vein Catheterization

  Baseline (immediately after endotracheal intubation) and 5 minutes after internal jugular vein catheterization

• Change in Internal Carotid Artery End-Diastolic Velocity (EDV) Following Internal Jugular Vein Catheterization

  Baseline and 5 minutes after internal jugular vein catheterization

• Change in Internal Carotid Artery Time-Averaged Maximum Velocity (TAMAX) Following Internal Jugular Vein Catheterization

  Baseline and 5 minutes after internal jugular vein catheterization

• Change in Internal Carotid Artery Pulsatility Index (PI) Following Internal Jugular Vein Catheterization

  Baseline and 5 minutes after internal jugular vein catheterization

• Change in Internal Carotid Artery Systolic/Diastolic Ratio (S/D) Following Internal Jugular Vein Catheterization

  Baseline and 5 minutes after internal jugular vein catheterization

Study Arms (1)

Adult Patients Undergoing Internal Jugular Vein Catheterization

Adults undergoing elective surgery under general anesthesia who require internal jugular vein catheterization as part of routine clinical care. Intracranial pressure will be assessed noninvasively using optic nerve sheath diameter measurements obtained before and after catheterization.

Procedure: Internal Jugular Vein Catheterization

Interventions

Internal Jugular Vein Catheterization PROCEDURE

Internal jugular vein catheterization is performed in patients undergoing major surgical procedures when clinically indicated as part of routine perioperative care. The procedure is not assigned by the study. Additional non-invasive ultrasound measurements, including optic nerve sheath diameter assessment, are obtained to evaluate physiological changes associated with catheterization without altering standard clinical management. Ultrasonography is a non-invasive and safe imaging method routinely used in clinical practice.

Adult Patients Undergoing Internal Jugular Vein Catheterization

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients undergoing surgical procedures under general anesthesia at a tertiary care hospital, in whom internal jugular vein catheterization is performed as part of routine clinical care.

You may qualify if:

• Age ≥18 years
• Patients undergoing surgery under general anesthesia
• Patients requiring internal jugular vein catheterization as part of routine clinical care
• Ability to obtain optic nerve sheath diameter measurements using transorbital ultrasonography
• Provision of informed consent

You may not qualify if:

• Known intracranial pathology affecting intracranial pressure
• Ocular conditions preventing accurate ultrasonographic measurement (e.g., orbital trauma, ocular surgery, infection)
• Hemodynamic instability
• Contraindication to internal jugular vein catheterization
• Inability to obtain adequate ultrasound images

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, Istanbul, Turkey (Türkiye)

Location

Related Publications (3)

• Robba C, Santori G, Czosnyka M, Corradi F, Bragazzi N, Padayachy L, Taccone FS, Citerio G. Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: a systematic review and meta-analysis. Intensive Care Med. 2018 Aug;44(8):1284-1294. doi: 10.1007/s00134-018-5305-7. Epub 2018 Jul 17.

  PMID: 30019201 BACKGROUND

• Dubourg J, Javouhey E, Geeraerts T, Messerer M, Kassai B. Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis. Intensive Care Med. 2011 Jul;37(7):1059-68. doi: 10.1007/s00134-011-2224-2. Epub 2011 Apr 20.

  PMID: 21505900 BACKGROUND

• Geeraerts T, Merceron S, Benhamou D, Vigue B, Duranteau J. Non-invasive assessment of intracranial pressure using ocular sonography in neurocritical care patients. Intensive Care Med. 2008 Nov;34(11):2062-7. doi: 10.1007/s00134-008-1149-x. Epub 2008 May 29.

  PMID: 18509619 BACKGROUND

Central Study Contacts

Ayça Sultan Şahin, Prof. Dr.

CONTACT

+905323100840; aycasultan@gmail.com

Aysun Edehan, MD

CONTACT

+905309127017; aysn.997@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 26, 2026
• First Posted: April 20, 2026
• Study Start: April 15, 2026
• Primary Completion (Estimated): March 15, 2027
• Study Completion (Estimated): March 16, 2027
• Last Updated: April 20, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)