Telerehabilitation in Patients With Bronchiectasis

NCT07539571 | Not Yet Recruiting

• 1 other identifier: TRH-BQ
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Home-based telerehabilitation (TR) has demonstrated benefits comparable to conventional rehabilitation in patients with chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. However, TR has not been thoroughly investigated in patients with bronchiectasis, despite evidence suggesting improvements in exercise capacity and quality of life. Aims: To evaluate the effects of TR on functional capacity, quality of life, and inflammatory biomarkers, as well as its safety in patients with bronchiectasis. Study design: Single-center randomized controlled trial with a parallel-group design. Methods: Patients diagnosed with bronchiectasis will be recruited from the Surgical Medical Unit for Respiratory Diseases at Virgen del Rocío University Hospital. Participants will be randomly assigned to one of two groups: a control group receiving usual care, and a TR group undergoing supervised physical training for 12 weeks, three times per week. Outcome measures will include the 6-minute walk test, quality-of-life questionnaires, pulmonary function tests, symptom assessment, and adverse event recording, as well as sputum microbiology and analysis of inflammatory biomarkers. Assessments will be conducted at baseline and at the end of the intervention. Expected results: A 12-week TR program is expected to significantly improve exercise capacity and quality of life in the intervention group. Additionally, this study may contribute to the development of future clinical guidelines regarding the use of TR in patients with bronchiectasis.

Conditions

Bronchiectasis; Telerehabilitation

Keywords

Bronchiectasis; Telerehabilitation; Quality of life; Inflammation

Outcome Measures

Primary Outcomes (1)

• 6-minute walk distance

  Patients walk through a 30-meter corridor faster than they can for 6 minutes

  Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

Secondary Outcomes (14)

• The quality of life

  Baseline, after 12 weeks of telerehabilitation program and at 3 and 6 months after completing the telerehabilitation program.

• Pulmonary function tests

  Baseline and after 12 weeks of telerehabilitation program.

• Respiratory Muscle Strength

  Baseline and after 12 weeks of telerehabilitation program.

• Exahled Nitric Oxide Fraction (FeNO)

  Baseline and after 12 weeks of telerehabilitation program.

• Sputum microbiology

  Baseline, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

Study Arms (2)

Usual care group

NO INTERVENTION

Standard care for exacerbation and follow-up without rehabilitation.

Exercise group

EXPERIMENTAL

Telerehabilitation: 12 weeks of supervised exercise interventions.

Other: telerehabilitation

Interventions

telerehabilitation OTHER

3 days per week: supervised resistance training that includes upper and lower limb and core exercises, initially using with low weights, performed in 2 sets with 10 repetitions, with progressive weekly increases depending on symptoms. 4 days per week: endurance training. Patients will walk on days when they do not perform strength training, for at least 30 minutes, with the duration gradually increased each month depending on their symptoms.

Also known as: physical activity

Exercise group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Bronchiectasis diagnosed by high resolution computed tomography (HRCT) of the chest.
• Clinically stable patients (without hospitalizations, infection or changes in pharmacological treatment in the last month of the study beginning).
• Both gender
• Non smokers.
• Internet connection available.

You may not qualify if:

• Inability to give informed consent to participate
• Less of 18 years
• With other lung related diseases (asthma, COPD and cystic fibrosis)
• Decompensated cardiovascular and metabolic diseases, neuromuscular or musculoskeletal that impede the realization of the protocol.
• Mental disorders that prevent the adequate participation in the tele-rehabilitation program.
• Simultaneous participation in another clinical trial.

Sponsors & Collaborators

• Hospitales Universitarios Virgen del Rocío: lead

Study Sites (1)

Hospital Universitario Virgen del Rocío

Seville, Sevilla, 41013, Spain

Location

MeSH Terms

Conditions

Bronchiectasis; Inflammation

Interventions

Telerehabilitation; Exercise

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services; Telemedicine; Delivery of Health Care; Patient Care Management; Health Services Administration; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Student

Study Record Dates

• First Submitted: December 15, 2025
• First Posted: April 20, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): December 1, 2031
• Study Completion (Estimated): December 1, 2032
• Last Updated: April 20, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)