Metabolic Regeneration Registry for Periodontal Health (20-Patient Cohort).

NCT07538661 | Completed

• 1 other identifier: ZIREG-ORAL-2026
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study documents the clinical outcomes of a proprietary, safe-to-swallow metabolic protocol for chronic gum disease. Based on 21 years of research and a focused 20-patient cohort, the study records visible clinical improvements in gingival inflammation and tissue color within 7 to 14 days. The protocol focuses on restoring the metabolic environment to achieve non-surgical periodontal pocket stabilization and natural tissue re-attachment.

Conditions

Chronic Periodontitis; Chronic Periodontitis Wth Diabetes Mellitus; Non-surgical Periodontal Treatment; Gingival Regeneration; Metabolic Repair

Keywords

Gingival Regeneration; Metabolic Repair; Non-Surgical Periodontal Treatment

Outcome Measures

Primary Outcomes (1)

• Visible reduction in gingival inflammation and erythema (redness) observed within 7 to 14 days

  7 to 14 days

Secondary Outcomes (1)

• Measurement of periodontal pocket depth reduction and tissue stability at 6 weeks

  6 weeks

Interventions

Nutraceutical Bio-Active Oral Repair Formula (Food-Grade) DIETARY_SUPPLEMENT

Topical application of a proprietary, 100% food-grade (GRAS) nutraceutical formulation specifically designed for rapid gingival tissue regeneration and inflammation reversal. Key Performance Indicators: Speed: Clinical onset of action visible within 3 days. Safety: Completely safe for ingestion (edible), eliminating common side effects of chemical antiseptics like staining or taste alteration. Efficacy: Significant reduction in redness and bleeding (BOP) within 7 to 14 days, as demonstrated in our cohort of 20+ subjects. Mechanism: Supports the natural healing of the gum 'peau' (epithelium) through host-response modulation rather than harsh disinfection.

Nutraceutical Bio-Active Oral Repair Formula DIETARY_SUPPLEMENT

Topical application of a proprietary, 100% food-grade (GRAS) nutraceutical formulation specifically designed for rapid gingival tissue regeneration and inflammation reversal.Key Performance Indicators: Speed: Clinical onset of action visible within 3 days. Safety: Completely safe for ingestion (edible), eliminating common side effects of chemical antiseptics like staining or taste alteration. Efficacy: Significant reduction in redness and bleeding (BOP) within 7 to 14 days, as demonstrated in our cohort of 20+ subjects. Mechanism: Supports the natural healing of the gum 'peau' (epithelium) through host-response modulation rather than harsh disinfection."

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 18 to 75 years diagnosed with chronic periodontitis, characterized by gingival inflammation, bleeding on probing, and periodontal pocket depths of 4mm or greater. The population includes individuals seeking non-surgical alternatives for gum tissue recovery.

You may qualify if:

• Patients (18-75) with documented chronic periodontitis and pocket depths \>4mm.

You may not qualify if:

• Active oral malignancy or pregnancy

Sponsors & Collaborators

• Amar h Zireg: lead
• Self funded: collaborator

Study Sites (1)

Zireg

Bordj Bou Arreridj, Wilaya de Bordj Bou Arréridj, 34000, Algeria

Location

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: sponsor investigator

Study Record Dates

• First Submitted: April 13, 2026
• First Posted: April 20, 2026
• Study Start: January 3, 2026
• Primary Completion: February 20, 2026
• Study Completion: February 26, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Locations

AL (1)