NCT06400069

Brief Summary

The quantification of NLRP6 in blood samples will be analyzed from individuals with chronic periodontitis but without systemic disease. Demographic and periodontal parameters will be assessed and correlated with the NLRP6 quantification using RT-PCR.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Dec 2024

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 30, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 6, 2024

Completed
7 months until next milestone

Study Start

First participant enrolled

December 13, 2024

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2025

Completed
9 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 22, 2025

Completed
Last Updated

November 24, 2025

Status Verified

April 1, 2025

Enrollment Period

3 months

First QC Date

April 30, 2024

Last Update Submit

November 21, 2025

Conditions

Chronic Periodontitis

Keywords

NLRP6 Protein, humanChronic Periodontitis

Outcome Measures

Primary Outcomes (1)

  • Quantification of NLRP6 gen, Quantification of NLRP6 gen using RT-PCR

    12 months

Interventions

Evaluation of serum NLRP6 levelsOTHER

intervention: Evaluation of serum NLRP6 levels control: Evaluation of serum NLRP6 levels

Eligibility Criteria

Age25 Years - 79 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients referred to the periodontology department of the University School of Dentistry Medical sciences of Babol

You may qualify if:

  • Age: At least 25 years old
  • Clinical diagnosis of chronic periodontitis
  • At least 15 teeth in the mouth

You may not qualify if:

  • premalignant lesions and cancer of the oral cavity
  • periodontal treatment in the last 6 months
  • systemic disorders affecting the periodontal condition (autoimmunity and endocrine disorders)
  • diabetes mellitus and rheumatoid arthritis
  • pregnancy or breastfeeding
  • taking drugs with the possibility of affecting the periodontal condition (calcium channel blockers, anticonvulsants, etc.)
  • Smoking
  • aggressive PD

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dental School, Periodontology Department

Babol, Iran

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

PeriodontitisPeriodontal DiseasesMouth DiseasesStomatognathic DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Morteza Rabbani, DS

Study Record Dates

First Submitted

April 30, 2024

First Posted

May 6, 2024

Study Start

December 13, 2024

Primary Completion

February 28, 2025

Study Completion

November 22, 2025

Last Updated

November 24, 2025

Record last verified: 2025-04

Locations

IR(1)