NCT06400069

Completed

Role of NLRP6 in Chronic Periodontitis

Babol University of Medical Sciences Source

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Other study identifiers

Sponsor study identifier

IR.MUBABOL.REC.1403.037

Study Type

observational

Actual enrollment (reported)

50

Locations

1 country

Sites

1

Timeline

Study Start

December 13, 2024

Actual (reported)

Primary Completion

February 28, 2025

Actual (reported)

Study Completion

November 22, 2025

Actual (reported)

Brief Summary

The quantification of NLRP6 in blood samples will be analyzed from individuals with chronic periodontitis but without systemic disease. Demographic and periodontal parameters will be assessed and correlated with the NLRP6 quantification using RT-PCR.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 50 participants
Study completion date: November 22, 2025
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
April 30, 2024
Actual (reported)
First Posted
May 6, 2024
Actual (reported)
Study Start
December 13, 2024
Actual (reported)
Primary Completion
February 28, 2025
Actual (reported)
Study Completion
November 22, 2025
Actual (reported)

Last Updated: November 24, 2025
Status Verified: April 2025
Last Update Submitted: November 21, 2025

Conditions

Chronic Periodontitis

Keywords

NLRP6 Protein, humanChronic Periodontitis

Outcome Measures

Primary Outcomes (1)

Quantification of NLRP6 gen, Quantification of NLRP6 gen using RT-PCR
12 months

Interventions

Evaluation of serum NLRP6 levelsOther

intervention: Evaluation of serum NLRP6 levels control: Evaluation of serum NLRP6 levels

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age25 Years - 79 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Patients referred to the periodontology department of the University School of Dentistry Medical sciences of Babol

You may qualify if:

Age: At least 25 years old

Sponsors & Collaborators

Babol University of Medical Sciences
Otherlead

Study Sites (1)

Dental School, Periodontology Department

Babol, Iran

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

PeriodontitisPeriodontal DiseasesMouth DiseasesStomatognathic DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Enrollment

50 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Morteza Rabbani, DS

Study Record Dates

First Submitted

April 30, 2024

First Posted

May 6, 2024

Study Start

December 13, 2024

Actual (reported)

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Not ApplicableRecruiting

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Phase 3Completed

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Completed

NCT07184268

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Not ApplicableCompleted

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Clinical diagnosis of chronic periodontitis

At least 15 teeth in the mouth

You may not qualify if:

premalignant lesions and cancer of the oral cavity
periodontal treatment in the last 6 months
systemic disorders affecting the periodontal condition (autoimmunity and endocrine disorders)
diabetes mellitus and rheumatoid arthritis
pregnancy or breastfeeding
taking drugs with the possibility of affecting the periodontal condition (calcium channel blockers, anticonvulsants, etc.)
Smoking
aggressive PD

Contact the study team to confirm eligibility.

Primary Completion

February 28, 2025

Actual (reported)

Study Completion

November 22, 2025

Actual (reported)

Last Updated

November 24, 2025

Record last verified: 2025-04

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT06400069
Data provider: ClinicalTrials.gov
Source updated: 2025-11-24
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:20:59 UTC

Locations

IR(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations