Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex Mechanisms

NCT07536997 | Completed DMC

• 2 other identifiers: 202309180123-50 and 24-30
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to compare the acute autonomic and hemodynamic effects of two arterial baroreflex resonance interventions-Resonance Breathing (RB) and Postural Resonance (PR)-in healthy young adults. Methods: A randomized crossover design was conducted in 27 healthy participants (aged 18-25). Each participant completed three experimental sessions (control, RB, and PR) separated by a 5-day washout period. Each session included a 15-minute baseline, a 15-minute intervention, and a 5-min recovery phase. Continuous recordings of skin sympathetic nerve activity (SKNA) and heart rate variability (HRV) were collected throughout each session, while blood pressure (BP) and pulse wave velocity (PWV) were measured before and after the interventions.

Conditions

Autonomic Nervous System Disease

Keywords

Arterial baroreflex; Autonomic nervous system; Skin sympathetic nerve activity; Blood pressure; Resonance intervention

Outcome Measures

Primary Outcomes (1)

• Skin sympathetic nerve activity

  Skin sympathetic nerve activity (SKNA) was recorded non-invasively at the chest wall using a dedicated SKNA monitoring system. Measurements were obtained at baseline (pre-intervention) and immediately following completion of the resonance breathing and postural resonance intervention, to assess acute changes in sympathetic nervous system activity.

  Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)

Secondary Outcomes (2)

• Changes in Resting Systolic and Diastolic Blood Pressure

  Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)

• Changes in Pulse Wave Velocity (PWV)

  Baseline (pre-intervention) and immediately post-intervention (within 5 minutes of intervention completion)

Study Arms (1)

Intervention Arm

EXPERIMENTAL

Participants receive structured Resonance Breathing and Postural Resonance training aimed at modulating baroreflex function, autonomic balance, and hemodynamic responses. All measurements are conducted at baseline and following intervention.

Behavioral: Resonance Breathing; Behavioral: Postural Resonance

Interventions

Resonance Breathing BEHAVIORAL

A structured intervention focusing on resonance breathing ( slow, rhythmic breathing at spontaneous resonance frequency ) . The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex.

Intervention Arm

Postural Resonance BEHAVIORAL

A structured intervention focusing on postural resonance alignment. The protocol aims to acutely modulate autonomic nervous system activity and hemodynamic responses via stimulation of the arterial baroreflex. Sessions include guided breathing practice, postural adjustment, and feedback on breathing mechanics

Intervention Arm

Eligibility Criteria

• Age: 18 Years - 30 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years old

You may not qualify if:

• No history of systematic professional sports training; Right-hand dominance (as assessed by the Edinburgh Handedness Inventory). Participants were excluded from the study if they had any of the following: Smoking, chronic alcohol consumption, or the use of psychotropic drugs or other substances affecting the nervous system; Irregular menstrual cycle; History of peripheral neuropathy or other autonomic nervous system disorders; Pre-existing cardiovascular diseases or abnormal electrocardiograms (ECG); Use of hormonal contraceptives; Uncontrolled hypertension or hypotension; Recent major life stressors; Regular practice of meditation or participation in psychotherapy; Presence of any movement disorders or inability to comprehend the experimental instructions.

Sponsors & Collaborators

• Beijing Sport University: lead

Study Sites (1)

No. 11, Gongyi Road, Dongcheng District, Beijing

Beijing, Dongcheng, 100010, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 12, 2026
• First Posted: April 17, 2026
• Study Start: May 1, 2024
• Primary Completion: June 15, 2024
• Study Completion: April 10, 2026
• Last Updated: April 17, 2026

Record last verified: 2024-04

Locations

CN (1)