Resonance Breathing Training for Long Covid-related Myocardial Injury

NCT06379672 | Not Yet Recruiting

• 1 other identifier: 2023[No.193]
• Study Type: interventional
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

An investigation of the efficacy of resonance breathing training in the rehabilitation of patients with Long covid-related myocardial injury

Conditions

Long COVID; Myocardial Injury

Keywords

2D-STE; resonance breathing; Myocardial Injury; Long Covid-19

Outcome Measures

Primary Outcomes (2)

• New YorkHeart Association (NYHA)

  The scale is divided into four levels Grade 1 is unrestricted activity. Daily physical activity does not cause significant shortness of breath, fatigue or palpitations Grade 2 is a mild limitation of activity. Asymptomatic at rest, daily activities may cause significant shortness of breath, fatigue or palpitations Grade 3 is marked limitation of activity. May be asymptomatic at rest, but may cause significant shortness of breath, fatigue, or palpitations with less than daily activity. Grade 4 is symptomatic at rest, with discomfort associated with any physical activity. Class IVa for those who can move around indoors or at the bedside without intravenous drug administration; Class IVb for those who cannot get out of bed and require intravenous drug administration.

  12weeks

• left ventricle global longitudinal strain, LVGLS

  The magnitude of overall longitudinal myocardial strain in the left ventricle on two-dimensional speckle tracking echocardiograms as an average of the peak longitudinal strain in all myocardial segments. The normal range is (-25% to -17%) in men and (-25% to -18%) in women.

  12weeks

Secondary Outcomes (2)

• hypertension

  12weeks

• Average heart rate

  12weeks

Study Arms (1)

intervention group

EXPERIMENTAL

Subjects were asked to remain in a standing position with their feet shoulder-width apart. The right hand was placed on the chest and the left hand on the abdomen. Inhale to make the abdomen bulge and exhale to make the abdomen sink (inhale through the nose and exhale through the mouth). This was done 2 times a day, once in the morning and once in the afternoon. Complete 3 sets of 8 breaths each. Each breath lasts 10 seconds (4 seconds inhaling and 6 seconds exhaling).

Other: Resonance breathing

Interventions

Resonance breathing OTHER

Resonant breathing was used on the subjects, using nasal inhalation and oral exhalation, for a total of 12 weeks.

intervention group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 60 years;
• According to the WHO definition: one or more systemic involvement present 3 months after the diagnosis of a new crown infection, and at least 2 of these months cannot be explained by other diseases
• D-STE suggestive of GLSAVG: -17% ≤ men ≤ -10%, -18% ≤ women ≤ -10%;
• Consent for enrollment based on the degree of myocardial injury, as diagnosed by a clinician;
• Signing the informed consent form with the consent of the patient or his/her family members

You may not qualify if:

• (1) Previous history of coronary atherosclerotic heart disease and heart failure; (2) Combination of severe arrhythmia or cardiogenic shock; (3) Combination of severe hypertension, hypertrophic cardiomyopathy, valvular disease of moderate or higher grade, acute myocarditis or pericarditis; (4) Combination of any disease that severely affects limb movement, such as musculoskeletal system disease or severe hepatic or renal insufficiency; (5) Combination of progressive malignant tumors, infectious diseases, bleeding disorders, autoimmune diseases, etc; Those who have serious mental illness and are unable to cooperate

Sponsors & Collaborators

• Chengdu Sport University: lead

MeSH Terms

Conditions

Post-Acute COVID-19 Syndrome

Condition Hierarchy (Ancestors)

COVID-19; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Rui Li

CONTACT

17711524016; wp100331@cdsu.edu.cn

Rui Li

CONTACT

17711524016

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: April 18, 2024
• First Posted: April 23, 2024
• Study Start: August 25, 2024
• Primary Completion: September 25, 2024
• Study Completion: October 5, 2024
• Last Updated: July 30, 2024

Record last verified: 2024-07