The Impact of Extreme Environmental and Security Conditions on Prematurity and Low Birth Weight Rates

NCT07531134 | Active Not Recruiting

• 1 other identifier: 0015-26-HYMC-IL
• Study Type: observational
• Target: 100,000
• Locations: 1 country
• Sites: 1

Brief Summary

Numerous reports indicate that various extreme environmental and security-related situations during pregnancy may increase the risk of prematurity, LBW, and miscarriage, as these events increase both the incidence and intensity of maternal stress. Study Objective: To map and validate this phenomenon within the catchment area of the Hillel Yaffe Medical Center.

Conditions

Low Birth Weight; Prematurity

Keywords

low birth weight; prematurity; extreme environmental and security-related situations

Outcome Measures

Primary Outcomes (1)

• Prematurity OR LBW rate per month

  prematurity or low birth weight rate

  25 years

Study Arms (2)

extreme environmental and security-related situations

pandemics, wars, economic collapses, and environmental disasters, such as earthquakes or storms

Other: No intervention

No extreme environmental and security-related situations

All other times

Other: No intervention

Interventions

No intervention OTHER

Only collecting the number of newborn infants in each group. No intervention

No extreme environmental and security-related situations; extreme environmental and security-related situations

Eligibility Criteria

• Age: Up to 1 Day
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

All infants born in Hillel Yaffe medical center since 01/01/1995

You may not qualify if:

• None

Sponsors & Collaborators

• Hillel Yaffe Medical Center: lead

Study Sites (1)

Hillel Yaffe medical center

Hadera, 38100, Israel

Location

Related Publications (10)

• Lawler K, Behie A, Richardson A. A systematic review with meta-analysis on the effects of maternal exposure to natural disasters on human birth outcomes. Int J Hyg Environ Health. 2025 Sep;270:114670. doi: 10.1016/j.ijheh.2025.114670. Epub 2025 Sep 22.

  PMID: 40987029 BACKGROUND

• Harville EW, Xiong X, David M, Buekens P. The Paradoxical Effects of Hurricane Katrina on Births and Adverse Birth Outcomes. Am J Public Health. 2020 Oct;110(10):1466-1471. doi: 10.2105/AJPH.2020.305769. Epub 2020 Aug 20.

  PMID: 32816548 BACKGROUND

• Yao XD, Zhu LJ, Yin J, Wen J. Impacts of COVID-19 pandemic on preterm birth: a systematic review and meta-analysis. Public Health. 2022 Dec;213:127-134. doi: 10.1016/j.puhe.2022.10.015. Epub 2022 Oct 19.

  PMID: 36410118 BACKGROUND

• Nagel LE, Reisch B, Schwenk U, Kimmig KR, Darkwah Oppong M, Dzietko M, Gellhaus A, Iannaccone A. Impact of 2 years of COVID-19 pandemic on preterm birth: Experience from a tertiary center of obstetrics in western Germany. Int J Gynaecol Obstet. 2024 Jul;166(1):404-411. doi: 10.1002/ijgo.15379. Epub 2024 Jan 17.

  PMID: 38230894 BACKGROUND

• Riquelme-Gallego B, Ramos-Soberbio L, Leno-Duran E, Martinez-Vazquez S, Caparros-Gonzalez RA. Adverse fetal and neonatal impact of war conflicts during pregnancy: A systematic review. IUBMB Life. 2025 Feb;77(2):e70006. doi: 10.1002/iub.70006.

  PMID: 39981676 BACKGROUND

• Bouachba A, Gorincour G, Charlier P, Ville Y. Pregnancy in Times of War: What Are the Fallouts? A Review. Fetal Diagn Ther. 2024;51(6):559-570. doi: 10.1159/000540508. Epub 2024 Jul 24.

  PMID: 39047700 BACKGROUND

• Cheung PY, Alshaikh B, Yang C. COVID-19 Pandemic: Different Associative Relationships of City Lockdown With Preterm Births in Three Cities - An Ecological Study. Front Pediatr. 2021 Apr 15;9:644771. doi: 10.3389/fped.2021.644771. eCollection 2021.

  PMID: 33937150 BACKGROUND

• Eiriksdottir VH, Asgeirsdottir TL, Bjarnadottir RI, Kaestner R, Cnattingius S, Valdimarsdottir UA. Low birth weight, small for gestational age and preterm births before and after the economic collapse in Iceland: a population based cohort study. PLoS One. 2013 Dec 4;8(12):e80499. doi: 10.1371/journal.pone.0080499. eCollection 2013.

  PMID: 24324602 BACKGROUND

• Hochard J, Li Y, Abashidze N. Associations of hurricane exposure and forecasting with impaired birth outcomes. Nat Commun. 2022 Nov 8;13(1):6746. doi: 10.1038/s41467-022-33865-x.

  PMID: 36347839 BACKGROUND

• Staude B, Misselwitz B, Louwen F, Rochwalsky U, Oehmke F, Kohler S, Maier RF, Windhorst AC, Ehrhardt H. Characteristics and Rates of Preterm Births During the COVID-19 Pandemic in Germany. JAMA Netw Open. 2024 Sep 3;7(9):e2432438. doi: 10.1001/jamanetworkopen.2024.32438.

  PMID: 39254973 BACKGROUND

MeSH Terms

Conditions

Premature Birth

Condition Hierarchy (Ancestors)

Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Erez Nadir, MD

  Hillel Yaffe Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Neonatologist

Study Record Dates

• First Submitted: April 6, 2026
• First Posted: April 15, 2026
• Study Start: January 1, 1990
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2028
• Last Updated: April 15, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)