The Effect of Systemic Factors on Peri-implant Health Status and Clinical Indices

NCT07530211 | Completed

• 1 other identifier: 2026/9630
• Study Type: observational
• Target: 93
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-sectional study evaluates the impact of systemic risk factors, including diabetes mellitus, smoking, cardiovascular disease, and osteoporosis, on peri-implant health status and clinical indices. The study included 93 patients with a total of 314 implants that have been in function for at least three years. The primary goal is to determine how these systemic conditions influence the prevalence of peri-implant mucositis and peri-implantitis.

Conditions

Peri-implantitis; Dental Implants; Peri-implant Mucositis

Keywords

Diabetes Mellitus; Smoking; Cardiovascular Disease; Osteoporosis; Peri-implant Health

Outcome Measures

Primary Outcomes (1)

• Prevalence of Peri-implant Diseases

  Distribution of dental implants categorized into three status groups: healthy, peri-implant mucositis, and peri-implantitis based on clinical and radiographic criteria

  Minimum 3 years post-loading veya At clinical assessment, at least 3 years after implant loading

Secondary Outcomes (3)

• Gingival Index (GI)

  At least 3 years after implant loading

• Plaque Index (PI)

  At least 3 years after implant loading.

• Probing Depth (PD)

  At least 3 years after implant loading.

Study Arms (5)

Smoking Group

Patients who are current smokers or use tobacco products

Other: Clinical and Radiographic Periodontal Assessment

Diabetes Mellitus Group

Patients diagnosed with diabetes mellitus

Other: Clinical and Radiographic Periodontal Assessment

Cardiovascular Disease Group

Patients with a history of cardiovascular diseases

Other: Clinical and Radiographic Periodontal Assessment

Osteoporosis Group

Patients diagnosed with osteoporosis

Other: Clinical and Radiographic Periodontal Assessment

Systemically Healthy Group

Individuals with no systemic diseases and no history of smoking

Other: Clinical and Radiographic Periodontal Assessment

Interventions

Clinical and Radiographic Periodontal Assessment OTHER

Clinical parameters (Plaque Index, Gingival Index, Probing Depth) and radiographic assessments were performed for each patient to determine peri-implant health status

Cardiovascular Disease Group; Diabetes Mellitus Group; Osteoporosis Group; Smoking Group; Systemically Healthy Group

Eligibility Criteria

• Age: 27 Years - 72 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of patients who visited the Department of Periodontology at Inonu University Faculty of Dentistry. The sample includes systemically healthy individuals and patients diagnosed with diabetes mellitus, cardiovascular disease, or osteoporosis, as well as current smokers.

You may qualify if:

• Patients with at least one dental implant in function for at least three years.
• Patients aged between 27 and 72 years.
• Availability of complete clinical and radiographic records.

You may not qualify if:

• Implants in function for less than 3 years.
• Pregnancy or lactation.
• History of radiation therapy in the head and neck region

Sponsors & Collaborators

• Inonu University: lead

Study Sites (1)

Inonu University Faculty of Dentistry

Battalgazi, Malatya, 44300, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Peri-Implantitis; Diabetes Mellitus; Smoking; Cardiovascular Diseases; Osteoporosis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 23, 2026
• First Posted: April 15, 2026
• Study Start: March 11, 2026
• Primary Completion: March 20, 2026
• Study Completion: March 23, 2026
• Last Updated: April 15, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: Data will be available beginning 6 months and ending 36 months following publication
• Access Criteria: Requests for data should be directed to the corresponding author via email. To gain access, data requestors will need to provide a methodologically sound proposal

Locations

TU (1)