Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

NCT07527871 | Not Yet Recruiting DMC

• 2 other identifiers: STUDY2025-00000054U01CE003825
• Study Type: interventional
• Target: 650
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner Medical Center.

Conditions

Substance Use (Drugs, Alcohol)

Keywords

substance use

Outcome Measures

Primary Outcomes (1)

• Self-reported substance use

  Self-reported substance use frequency

  From baseline to the sixth month follow-up assessment

Secondary Outcomes (5)

• Self-reported substance use quantity

  From baseline to the six month follow-up

• Incidence of positive substance use disorder screen

  From baseline to the six month follow-up

• Toxicology assays for substance use

  From baseline to the six month follow-up assessment

• Self-reported healthcare utilization

  Baseline to the six month follow-up assessment

• Fatal and non-fatal overdose

  Baseline to the six month follow-up assessment

Study Arms (2)

ED-SMART intervention

EXPERIMENTAL

The ED-SMART intervention includes: (i) a brief (approximately 15 minutes) counseling session in the emergency department and (ii) five, monthly brief counseling sessions (approximately 15 to 30 minutes) delivered by telehealth. These sessions will focus on creating individualized strategies to help participants reach their alcohol and substance use reduction goals.

Behavioral: ED-SMART intervention

Substance use information

PLACEBO COMPARATOR

The substance use information condition will receive printed health information covering information about substance use (e.g., definitions, hazards, potential for addiction, injury, and other consequences). Staff will also discuss ways to utilize primary care or establish care with a primary care provider to provide ongoing follow-up.

Behavioral: Substance use information

Interventions

ED-SMART intervention BEHAVIORAL

The ED-SMART intervention will include: (i) a brief (approximately 15 minutes) counseling session in the emergency department and (ii) five, monthly brief counseling sessions (approximately 15 to 30 minutes) delivered by telehealth. These sessions will focus on creating individualized strategies to help participants reach their alcohol and substance use reduction goals

ED-SMART intervention

Substance use information BEHAVIORAL

The substance use information condition will receive printed health information covering information about substance use (e.g., definitions, hazards, potential for addiction, injury, and other consequences). Research staff will also discuss ways to utilize primary care or establish care with a primary care provider to provide ongoing follow-up.

Substance use information

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult at least 18 years of age
• Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk.

You may not qualify if:

• A priori participant request for participation
• Concurrently enrolled in other study of substance use disorder prevention
• Prisoner at time of enrollment
• Known to be pregnant at time of enrollment
• Past substance use disorder or substance use treatment
• High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone

Sponsors & Collaborators

• Purdue University: lead
• Centers for Disease Control and Prevention: collaborator

MeSH Terms

Conditions

Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders

Study Officials

• Jennifer L. Brown, PhD

  Purdue University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jennifer L Brown, PhD

CONTACT

866-818-2620; jenniferbrown@purdue.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 7, 2026
• First Posted: April 14, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): September 1, 2029
• Study Completion (Estimated): September 1, 2029
• Last Updated: April 14, 2026

Record last verified: 2026-04