A High School Program for Preventing Prescription Drug Misuse

NCT03219190 | Completed Results DMC

• 1 other identifier: 1R44DA04327301
• Study Type: interventional
• Target: 1,804
• Locations: 1 country
• Sites: 1

Brief Summary

This project will develop and evaluate a program to prevent prescription drug misuse in high school students

Conditions

Substance Use (Drugs, Alcohol); Prescription Drug Abuse; Substance Abuse

Keywords

Adolescence; Prescription Drug Misuse; Prevention; Hybrid; E-learning; Cigarette Smoking; Alcohol Use; Life Skills

Outcome Measures

Primary Outcomes (1)

• Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription)

  This measure includes prescription drug misuse of sedatives, painkillers, and stimulants. Frequency of sedative, painkiller, and stimulant use without a doctor's prescription; measured on a 9-point scale, including Never (1), A few times but NOT in the past year (2), A few times a year (3), Once a month (4), A few times a month (5), Once a week (6), A few times a week (7), Once a day (8), More than once a day (9); Unabbreviated scale title: Prescription Drug Misuse (i.e., prescription drug use without a doctor's prescription); Minimum value = 1; maximum value = 9; Higher scores are a worse outcome

  Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

Secondary Outcomes (7)

• Alcohol Use

  Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

• Tobacco Use

  Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

• Marijuana Use

  Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

• Inhalant Use

  Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

• Substance Use Intentions

  Assessed at pre-test and post-test assessment, post-test assessment approximately 2-4 weeks post-intervention reported

Study Arms (2)

LST High School Hybrid

EXPERIMENTAL

Provided with the prevention program, consisting of e-learning modules and classroom sessions.

Behavioral: LST High School Hybrid

Treatment as Usual (Control)

NO INTERVENTION

Standard health education normally provided by the school

Interventions

LST High School Hybrid BEHAVIORAL

The preventive intervention for high school PDM will: (1) utilize both online e-learning modules and interactive classroom sessions to address PDM and concurrent alcohol/drug abuse; (2) positively change social norms surrounding PDM and alcohol/drug abuse; (3) change positive expectancies about the benefits of PDM; (4) discourage diversion of prescription medication; (5) enhance protective factors by building social, self-regulation, and relationship skills through interactive learning and behavioral rehearsal scenarios; and (6) include online booster sessions.

LST High School Hybrid

Eligibility Criteria

• Age: 14 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• High school aged-youth

You may not qualify if:

• All students in the classroom were eligible to participate in the intervention. However, at the discretion of local school staff, students with significant cognitive impairment or severe learning disabilities were excused from completing the study questionnaire.

Sponsors & Collaborators

• National Health Promotion Associates, Inc.: lead

Study Sites (1)

National Health Promotion Associates, Inc.

White Plains, New York, 10604, United States

Location

Related Publications (1)

• Retraction of "Preventing tobacco and alcohol use among high school students through a hybrid online and in-class intervention: A randomized controlled trial," by Williams et al. (2025). Psychol Addict Behav. 2026 Feb;40(1):125. doi: 10.1037/adb0001131.

  PMID: 41627337 DERIVED

MeSH Terms

Conditions

Substance-Related Disorders; Prescription Drug Misuse; Cigarette Smoking; Alcohol Drinking

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Drug Misuse; Tobacco Smoking; Smoking; Behavior; Tobacco Use; Drinking Behavior

Results Point of Contact

• Title: Christopher Williams
• Organization: National Health Promotion Associates, Inc

cwilliams@nhpamail.com

914-421-2525

Study Officials

• Christopher Williams, PhD, MPH

  National Health Promotion Associates, Inc.

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Research Scientist

Study Record Dates

• First Submitted: July 13, 2017
• First Posted: July 17, 2017
• Study Start: February 1, 2022
• Primary Completion: July 1, 2023
• Study Completion: July 1, 2023
• Last Updated: March 10, 2026
• Results First Posted: March 10, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)