Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation

NCT07526701 | Completed

• 1 other identifier: 2025-ke-783
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly anticoagulation strategies. This study aimed to evaluate the safety and feasibility of early 0.23-T MRI examination in ECPR patients. The investigators further assessed the image quality of the 0.23-T MRI and investigated the incidence and patterns of ABI, as well as their associations with neurological outcomes. This prospective observational study was conducted in the emergency intensive care unit (EICU) of Beijing Chaoyang Hospital, a high-volume ECPR center. The primary outcome was the feasibility of performing 0.23-T MRI in patients undergoing ECPR, defined as successful completion of the examination without serious adverse events (AEs).

Conditions

Cardiac Arrest (CA); Extracorporeal Cardiopulmonary Resuscitation; Acute Brain Injury

Keywords

Cardiac Arrest; Extracorporeal Cardiopulmonary Resuscitation; Acute brain injury; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• Feasibility of 0.23-T MRI examination

  Defined as the percentage of participants who successfully complete the MRI examination without experiencing serious adverse events (AEs). AEs include a decrease in ECMO flow \> 10%, a change in mean arterial pressure of ± 20%, or a change in minute ventilation \> 20%.

  From the initiation of the MRI scan until 6 hours after its completion.

Secondary Outcomes (3)

• Image Quality

  Within 6 hours after the completion of the MRI scan.

• Incidence of Acute Brain Injury (ABI)

  From the onset of cardiac arrest to the completion of the MRI scan

• The association between ABI and neurological outcomes

  3 months after ROSC.

Study Arms (1)

Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.

You may qualify if:

• Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.

You may not qualify if:

• age \< 18 years
• unwitnessed cardiac arrest
• pregnancy
• contraindications to MRI (except ECPR, for which safety with 0.23-T MRI has been proved)
• physical dimensions exceeding scanner limits
• refusal of consent by the family

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (1)

Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University

Beijing, Beijing Municipality, 100020, China

Location

Related Publications (1)

• Suo Y, Du W, Xie X, Jiang Q, Zhang Z, Xu Y, Wei N, Zhu W, Qi N, Wang N, Xue B, Wang Y, Jiang Y, Meng X, Li Z, Zhao X, Li H, Wang Y, Jing J. Detecting acute ischemic lesions using mobile, low-field MRI in TIA and minor stroke in the emergency room. Int J Stroke. 2026 Apr;21(4):475-484. doi: 10.1177/17474930251378850. Epub 2025 Sep 4.

  PMID: 40905643 RESULT

MeSH Terms

Conditions

Heart Arrest; Brain Injuries

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: April 4, 2026
• First Posted: April 13, 2026
• Study Start: November 1, 2024
• Primary Completion: January 1, 2026
• Study Completion: January 1, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)