Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore

NCT07525583 | Recruiting

• 1 other identifier: NICTran2023-0013
• Study Type: observational
• Target: 2,500
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the implementation of a structured community-based pathway to screen, risk stratify, and prevent decline in intrinsic capacity (IC) among adults aged 60 years and above in Singapore. Using the World Health Organization (WHO) Integrated Care for Older People (ICOPE) framework and digital screening tools, participants will undergo IC domain screening in community settings. Individuals identified with early decline will receive targeted multidomain interventions and/or referral to primary or specialist care as indicated. Participants will be followed longitudinally to assess feasibility, uptake, functional trajectories, and implementation outcomes.

Conditions

Frailty; Intrinsic Capacity; Lifestyle

Keywords

intrinsic capacity; personalized intervention; frailty; geroscience

Outcome Measures

Primary Outcomes (2)

• Prevalence of intrinsic capacity decline at baseline (robust / pre-frail)

  Proportion of participants (restricted to robust and pre-frail at baseline) with ≥1 impaired IC domain on screening; and proportion impaired by each domain (mobility, cognition, vitality, psychological, sensory).

  Baseline

• Uptake of recommended actions (implementation effectiveness)

  Proportion of participants who initiate at least one recommended action within a defined window after screening/plan (e.g., enrolment in a prescribed community programme, completion of recommended assessment, or attendance at a referred service).

  Up to 3 months post-recommendation

Secondary Outcomes (7)

• Identification of (a set of) biomarkers of aging

  30 months

• Feasibility and reach

  30 months

• Change in intrinsic capacity and function over time

  12 months from enrolment

• Frailty progression

  over 12 months follow up

• Cost per participant screened

  3 years

Study Arms (1)

Screen and Prevent Intrinsic Capacity Decline in Elders (SPICE)

Community-dwelling adults robust or pre-frail aged 60 years and above who undergo WHO ICOPE-aligned digital intrinsic capacity screening, structured risk stratification, personalised multidomain community-based interventions, and longitudinal follow-up.

Other: ICOPE-Based Digital Intrinsic Capacity Monitoring and Triggered Follow-up (SPICE Pathway)

Interventions

ICOPE-Based Digital Intrinsic Capacity Monitoring and Triggered Follow-up (SPICE Pathway) OTHER

Participants will undergo baseline intrinsic capacity (IC) screening using WHO ICOPE-aligned tools in community settings. Follow-up contacts/visits will occur over the study period and include: 1. Scheduled follow-up at predefined intervals (e.g., every 3, 6-12 months) for repeat IC assessment and outcome data collection; and 2. Triggered (non-scheduled) follow-up that is initiated when remote/digital monitoring indicates decline in one or more IC domains, poor adherence, or when major intercurrent clinical events are reported/identified, prompting in-depth assessment, care plan adjustment, and referral to Community Health Posts, primary care, or specialist services as appropriate.

Screen and Prevent Intrinsic Capacity Decline in Elders (SPICE)

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Recruitment will be conducted from Active Ageing Centre and Community Centres.

You may qualify if:

• pre-frail or robust older adults who can provide consent and follow instructions

You may not qualify if:

• frail or with terminal illness

Sponsors & Collaborators

• National University Hospital, Singapore: lead

Study Sites (1)

National University Hospital

Singapore, Singapore

RECRUITING

Related Links

• Description of the WHO ICOPE Framework

MeSH Terms

Conditions

Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Reshma Merchant (Associate Professor), MBChB (Edin)

CONTACT

+6567724368; mdcram@nus.edu.sg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 3, 2026
• First Posted: April 13, 2026
• Study Start: April 1, 2025
• Primary Completion (Estimated): May 30, 2027
• Study Completion (Estimated): September 30, 2027
• Last Updated: April 13, 2026

Record last verified: 2026-03

Locations

SG (1)