NCT07525245

Brief Summary

This is an interventional study targeting parents of junior high school girls. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates among parents' junior high school girls. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention among parents. All participants will be enrolled and randomly assigned to four groups: (1) vaccine chatbot plus scientific videos, (2) vaccine chatbot only, (3) scientific videos only, and (4) a control group (no intervention). The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. The scientific videos will cover content related to HPV vaccine safety, efficacy, and other relevant information. The study will compare changes in HPV vaccine awareness, vaccination intention, and vaccination behavior between the intervention groups and the control group after the intervention to evaluate whether the three intervention strategies enhance HPV vaccine awareness, vaccination intention, and vaccination uptake.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
18,000

participants targeted

Target at P75+ for not_applicable

Timeline
19mo left

Started May 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress7%
May 2026Dec 2027

First Submitted

Initial submission to the registry

April 6, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 13, 2026

Completed
23 days until next milestone

Study Start

First participant enrolled

May 6, 2026

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

April 15, 2026

Status Verified

April 1, 2026

Enrollment Period

1.7 years

First QC Date

April 6, 2026

Last Update Submit

April 10, 2026

Conditions

HPV Vaccination RatesHPV Vaccine AwarenessHPV Vaccination Intention

Keywords

HPV vaccineLarge language modelHPV vaccinationArtificial intelligenceChatbot

Outcome Measures

Primary Outcomes (1)

  • Human papillomavirus (HPV) vaccination rates for parents' junior high school girls in all groups before and after the intervention

    Whether junior high school girls get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

    Baseline and two months

Secondary Outcomes (2)

  • HPV vaccine awareness for eligible parents of junior high school girls in all groups before and after the intervention

    Baseline and two weeks

  • HPV vaccination intention for eligible parents of junior high school girls in all groups before and after the intervention

    Baseline and two weeks

Other Outcomes (3)

  • Vaccine chatbot acceptability and implementability

    Two weeks

  • Factors influencing vaccination intention for eligible female university students

    Two weeks and six months

  • HPV vaccination rates for parents' junior high school girls in all groups after the intervention

    Two weeks, one month and six months

Study Arms (4)

Vaccine chatbot + Watching scientific videos group

EXPERIMENTAL

The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information.

Device: Scientific videosDevice: Vaccine chatbot

Watching scientific videos group

EXPERIMENTAL

Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information.

Device: Scientific videos

Vaccine chatbot group

EXPERIMENTAL

The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions.

Device: Vaccine chatbot

Control group

NO INTERVENTION

No intervention

Interventions

Scientific videosDEVICE

Provide scientific videos related to HPV vaccine

Vaccine chatbot + Watching scientific videos groupWatching scientific videos group
Vaccine chatbotDEVICE

Provide vaccine chatbot to answer HPV vaccine questions

Vaccine chatbot + Watching scientific videos groupVaccine chatbot group

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Parents of junior high school girls.
  • Possess an electronic device with QR code scanning capability.
  • Junior high school girls have no contraindications to HPV vaccination.
  • No mental disorders or visual/reading impairments; able to cooperate with and implement the corresponding intervention activities.
  • Have provided informed consent and are willing to participate in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
professor

Study Record Dates

First Submitted

April 6, 2026

First Posted

April 13, 2026

Study Start

May 6, 2026

Primary Completion (Estimated)

December 31, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

April 15, 2026

Record last verified: 2026-04