Effectiveness of Large Language Model-Based Chatbot Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates

NCT07351604 | Not Yet Recruiting

• 1 other identifier: HPV-AI-001
• Study Type: interventional
• Target: 18,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is an interventional study targeting female university students. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention. All participants will be enrolled and randomly assigned to four groups: (1) vaccine chatbot plus scientific videos, (2) vaccine chatbot only, (3) scientific videos only, and (4) a control group (no intervention). The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. The scientific videos will cover content related to HPV vaccine safety, efficacy, and other relevant information. The study will compare changes in HPV vaccine awareness, vaccination intention, and vaccination behavior between the intervention groups and the control group after the intervention to evaluate whether the three intervention strategies enhance HPV vaccine awareness, vaccination intention, and vaccination uptake.

Conditions

HPV Vaccination Rates; HPV Vaccine Awareness; HPV Vaccination Intention

Keywords

HPV vaccine; chatbot; Large language model; AI; HPV vaccination

Outcome Measures

Primary Outcomes (1)

• HPV vaccination rates for female university students in all groups before and after the intervention

  Whether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

  Baseline and two months

Secondary Outcomes (2)

• HPV vaccine awareness for eligible female university students in all groups before and after the intervention

  Baseline and two weeks

• HPV vaccination intention for eligible female university students in all groups before and after the intervention

  Baseline and two weeks

Other Outcomes (3)

• Vaccine chatbot acceptability and implementability

  Two weeks

• Factors influencing vaccination intention for eligible female university students

  Two weeks and six months

• HPV vaccination rates for female university students in all groups after the intervention

  two weeks, one month and six months

Study Arms (4)

Vaccine chatbot + Watching scientific videos group

EXPERIMENTAL

The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information.

Device: Scientific videos; Device: Vaccine chatbot

Watching scientific videos group

EXPERIMENTAL

Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information.

Device: Scientific videos

Vaccine chatbot group

EXPERIMENTAL

The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions.

Device: Vaccine chatbot

Control group

NO INTERVENTION

No intervention

Interventions

Scientific videos DEVICE

Provide scientific videos related to HPV vaccine

Vaccine chatbot + Watching scientific videos group; Watching scientific videos group

Vaccine chatbot DEVICE

Provide vaccine chatbot to answer HPV vaccine questions

Vaccine chatbot + Watching scientific videos group; Vaccine chatbot group

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Female university students.
• Possess an electronic device with QR code scanning capability.
• Female university students have no contraindications to HPV vaccination.
• No mental disorders or visual/reading impairments; able to cooperate with and implement the corresponding intervention activities.
• Have provided informed consent and are willing to participate in the study.

Sponsors & Collaborators

• Xiamen University: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 25, 2025
• First Posted: January 20, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: March 31, 2026

Record last verified: 2026-03