Colorectal Adenoma Cohort

NCT07523035 | Not Yet Recruiting DMC

• 1 other identifier: 2026-0106
• Study Type: observational
• Target: 1,280
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is an ambidirectional cohort study aiming to develop and validate a risk prediction model for colorectal adenoma recurrence and progression. The study will enroll patients aged 18-75 years who undergo colorectal adenoma resection at the Second Affiliated Hospital of Zhejiang University School of Medicine. A retrospective cohort will include patients treated in the past 10 years with available endoscopic, pathologic, and routine laboratory data. A prospective cohort will be enrolled from the date of ethical approval until December 31, 2030, with collection of epidemiological questionnaire data, lifestyle information, blood and tissue biospecimens, and follow-up outcomes. The primary outcome is adenoma recurrence, with secondary outcomes including advanced adenoma and colorectal cancer. Based on a target of 1,083 evaluable participants (325 events) to ensure adequate model development, and accounting for 15% loss to follow-up, the total planned enrollment is 1,280 participants. The study will validate existing risk models based on traditional adenoma characteristics and establish a novel model incorporating lifestyle factors and systemic inflammatory markers to improve risk stratification and guide surveillance strategies.

Conditions

Colorectal Neoplasms

Keywords

colorectal neoplasms; surveillance

Outcome Measures

Primary Outcomes (1)

• colorectal adenoma recurrence

  3-year

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients who underwent adenoma resection

You may qualify if:

• Patients who underwent colonoscopy at our institution, were diagnosed with colorectal adenoma, and underwent adenoma resection.
• Aged between 18 and 75 years.
• Provide written informed consent voluntarily, with willingness to comply with follow-up procedures.
• For the retrospective cohort only: Regular follow-up colonoscopy at our institution within 1 to 5 years after adenoma resection.

You may not qualify if:

• Severe dysfunction of vital organs (e.g., heart, liver, kidney).
• Psychiatric disorders that preclude normal communication or compliance with study procedures.
• History of colorectal cancer.
• Recent receipt of radiotherapy or chemotherapy.
• Pregnancy or lactation.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Related Publications (2)

• He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M. Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps. Gastroenterology. 2020 Mar;158(4):852-861.e4. doi: 10.1053/j.gastro.2019.06.039. Epub 2019 Jul 11.

  PMID: 31302144 BACKGROUND

• Loberg M, Kalager M, Holme O, Hoff G, Adami HO, Bretthauer M. Long-term colorectal-cancer mortality after adenoma removal. N Engl J Med. 2014 Aug 28;371(9):799-807. doi: 10.1056/NEJMoa1315870.

  PMID: 25162886 BACKGROUND

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Officials

• Jun Li

  The 2nd affiliated hospital, Zhejiang University school of medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chengcheng Liu

CONTACT

+86057186995370; liuchengcheng@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 5, 2026
• First Posted: April 13, 2026
• Study Start: April 16, 2026
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2033
• Last Updated: April 13, 2026

Record last verified: 2026-04