NCT07522216

Brief Summary

The aim of this two-arm randomized clinical trial was to compare the effect of 7-day and 14-day orthodontic clear aligner wear protocols on external apical root resorption (EARR) and pain perception

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
52

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2025

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 2, 2025

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

January 15, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

April 13, 2026

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 15, 2026

Completed
Last Updated

April 13, 2026

Status Verified

April 1, 2026

Enrollment Period

1.2 years

First QC Date

January 15, 2026

Last Update Submit

April 3, 2026

Conditions

Clear Aligner Therapy

Keywords

Root resorptionAligner wearing protocol

Outcome Measures

Primary Outcomes (1)

  • Root resorption

    Peri-apical radiographs will be taken before and after the treatment, tooth root length will be measured before and after treatment from the radiographs

    6 months

Secondary Outcomes (1)

  • Pain perception

    After 24 hours, 1 week, 2 weeks, 1 month, 3 months and 6 months

Study Arms (2)

7-day aligner wearing protocol

ACTIVE COMPARATOR
Other: Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols

14-day aligner wearing protocol

ACTIVE COMPARATOR
Other: Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols

Interventions

Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocolsOTHER

One group should change the orthodontic clear aligner every week (7 days) and the second group every two weeks (14 days)

14-day aligner wearing protocol7-day aligner wearing protocol

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Participants with complete permanent dentition except wisdom teeth
  • Participants presented with mild to moderate malocclusion (Average degree of crowding).
  • Participants with good oral hygiene and absence of periodontal disease.
  • No history of trauma or prior orthodontic treatment.

You may not qualify if:

  • Participants with thin or petite roots.
  • Participants with pre-existing root resorption
  • Participants with endodontically treated incisors or canines.
  • Participants with history of trauma to incisors teeth
  • Participants with previous orthodontic treatment.
  • Participants with periapical pathology, ankylosisor cystic lesions.
  • Participants with medical conditions that may affecting pain or inflammatory responses.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

postgraduate orthodontic clinics at JUST

Irbid, 22110, Jordan

Location

MeSH Terms

Conditions

Root Resorption

Condition Hierarchy (Ancestors)

Tooth ResorptionTooth DiseasesStomatognathic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 15, 2026

First Posted

April 13, 2026

Study Start

February 2, 2025

Primary Completion

April 1, 2026

Study Completion

May 15, 2026

Last Updated

April 13, 2026

Record last verified: 2026-04

Locations

JO(1)