NCT07521865

Brief Summary

The investigators are adapting a tablet-based cognitive training program for Alzheimer's disease (AD) by focusing on specific cognitive components. It is aimed to demonstrate the feasibility, acceptability and usability of remote cognitive training in older adults with Mild Cognitive Impairment (MCI) and AD dementia. The study involves 36 participants in three groups, with a two-week intervention and focus groups for refinement.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
52

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jun 2023

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2023

Completed
2.5 years until next milestone

First Submitted

Initial submission to the registry

November 17, 2025

Completed
5 months until next milestone

First Posted

Study publicly available on registry

April 13, 2026

Completed
17 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2026

Completed
Last Updated

June 26, 2026

Status Verified

April 1, 2026

Enrollment Period

2.9 years

First QC Date

November 17, 2025

Last Update Submit

June 25, 2026

Conditions

Remote Cognitive TrainingAlzheimer DiseaseMild Cognitive ImpairmentOld Age; DementiaSerious GamesApp-based Cognitive Training

Keywords

Alzheimer's DiseaseRemote technologyCognitive trainingOld Age Psychiatry

Outcome Measures

Primary Outcomes (1)

  • Feasibility of tablet-based cognitive training

    Compliance rate (i.e.number of sessions completed)

    Assessed at the end of the 2-week intervention (Day 10)

Secondary Outcomes (4)

  • Feasibility of tablet-based cognitive training

    Assessed at the end of the 2-week intervention (Day 10)

  • Usability

    Assessed at the end of the 2-week intervention (Day 10)

  • Acceptability

    Assessed within two weeks after day 10 of the intervention

  • 2. Feasibility of tablet-based cognitive training

    Assessed at the end of the 2-week intervention (Day 10)

Other Outcomes (4)

  • Support 1

    Assessed at the end of the 2-week intervention (Day 10)

  • Support 2

    Assessed at the end of the 2-week intervention (Day 10)

  • Wellbeing

    Assessed every day during the intervention, a couple of seconds before playing the games (answering the in-game question on the tablet precedes playing the scheduled session).

  • +1 more other outcomes

Study Arms (3)

HC - Healthy Control Group

Healthy, age- and sex-matched participants (cognitively normal)

Device: App-based cognitive training

MCI - Mild Cognitive Impairment

Participants with MCI

Device: App-based cognitive training

AD - Alzheimer's Disease

Participants with mild-moderate stage dementia due to AD

Device: App-based cognitive training

Interventions

App-based cognitive trainingDEVICE

The cognitive training is administered remotely for 2 weeks daily (10 sessions). The participants play all 12 games for 8 minutes in each session.

AD - Alzheimer's DiseaseHC - Healthy Control GroupMCI - Mild Cognitive Impairment

Eligibility Criteria

Age70 Years - 95 Years
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants will be recruited by newspaper adverts and flyers after public talks. It is also intended to recruit visitors from the day clinic as well as patients from the Interdisciplinary Memory Clinic (IDMC) Bern (https://www.memory-clinic-bern.ch/) and the Domicil care home group (www.domicilbern.ch).

You may qualify if:

  • Informed Consent as documented by signature
  • Study partners:
  • Native or fluent German speaker
  • Participants:
  • Are able to give their consent to participate in the study
  • Age between 70 and 95 years
  • Native or fluent German speaker
  • Normal or corrected to normal vision and hearing
  • Ability to visit the study location repeatedly
  • MoCA score \> 11

You may not qualify if:

  • Substance abuse
  • Severe neurological or psychiatric conditions (of note: patients with mild depressive symptoms not fulfilling the criteria for major depressive disorder will be recruited into the sample to better represent clinical reality)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital of Old Age Psychiatry and Psychotherapy Bern

Bern, Canton of Bern, 3000, Switzerland

Location

Related Links

MeSH Terms

Conditions

Alzheimer DiseaseCognitive Dysfunction

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental DisordersCognition Disorders

Study Officials

  • Anna-Katharine Brem

    University Hospiltal of Old Age Psychiatry and Psychotherapy

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 17, 2025

First Posted

April 13, 2026

Study Start

June 1, 2023

Primary Completion

April 30, 2026

Study Completion

April 30, 2026

Last Updated

June 26, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

The investigators will share encrypted study data used for publications in an appropriate open access data base

Locations

CH(1)