Physiotherapy and Rehabilitation in Melorheostosis: A Case Report

NCT07521150 | Active Not Recruiting

• 1 other identifier: yeditepe01
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the effects of a structured physiotherapy and rehabilitation-based exercise program on clinical and functional parameters in a patient diagnosed with melorheostosis. This study specifically aims to assess the effects of a structured physiotherapy and rehabilitation-based intervention program, including patient education and therapeutic exercise, on lower extremity functional parameters, muscle strength, balance, and quality of life in a patient with melorheostosis. The main hypotheses: H0: A structured physiotherapy and rehabilitation-based exercise program has no effect on improvement in clinical and functional evaluation parameters in a patient with melorheostosis. H1: A structured physiotherapy and rehabilitation-based exercise program leads to improvement in clinical and functional evaluation parameters in a patient with melorheostosis.

Conditions

Melorheostosis

Keywords

Physical Therapy; Rehabilitation; Sclerosing Bone Disease; Case Report; Exercise

Outcome Measures

Primary Outcomes (1)

• Pain Assessment

  The Visual Analog Scale (VAS) was used to evaluate pain intensity. The location and severity of the pain will be questioned. The individual's resting, activity, and nighttime pain levels were evaluated on a 10 cm horizontal line with the extremes of "0: no pain" and "10: unbearable pain". Higher values indicate severe pain. In this study, it is planned to be used to evaluate the pain intensity of the case.

  Baseline (Week 0), Post-intervention (Week 8), and Follow-up (Month 6)

Secondary Outcomes (12)

• SF-12 Quality of Life Scale

  Baseline (Week 0), Week 8, and Month 6.

• Passive Knee Extension (PKE) Test

  Baseline (Week 0), Week 8, and Month 6.

• Ankle Active Range of Motion

  Baseline (Week 0), Week 8, and Month 6.

• Quadriceps Flexibility / Ely's Test

  Baseline (Week 0), Week 8, and Month 6.

• Gastrocnemius-Soleus Muscle Flexibility Tests

  Baseline (Week 0), Week 8, and Month 6.

Study Arms (1)

Structured Physiotherapy and Rehabilitation Program Group (SPTR-G)

EXPERIMENTAL

The target population of the study consists of a 24-year-old female case diagnosed with melorheostosis by a relevant physician, who voluntarily meets the inclusion criteria. The study is designed as a single-case report and aims to evaluate the clinical and functional characteristics of the case. The participant is actively working as a physiotherapist in her professional life. Patient will receive patient education in addition to a structured exercise program. The exercise program will include progressive strengthening, flexibility, and balance-based exercises. Patient education will be delivered by targeting topics that encompass all components of the ICF framework. In addition, diaphragmatic breathing will be taught to patients prior to the exercise program.

Other: Assigned Interventions

Interventions

Assigned Interventions OTHER

Patient will receive patient education in addition to a structured exercise program. The exercise program will include progressive strengthening, flexibility, and balance-based exercises. Patient education will be delivered by targeting topics that encompass all components of the ICF framework. In addition, diaphragmatic breathing will be taught to patients prior to the exercise program. The exercise program will be conducted three times per week for 8 weeks. Baseline assessments will be performed before the intervention, and post-intervention assessments will be repeated after completion of the program. Furthermore, evaluations will be conducted again during a 6-month follow-up period.

Structured Physiotherapy and Rehabilitation Program Group (SPTR-G)

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed with melorheostosis by a physician.
• Voluntarily agreeing to participate in the study and providing written informed consent.
• Being under physician follow-up for the disease.
• Being 18 years of age or older.
• Having the cognitive level, communication skills, and physical capacity to perform the planned exercise program.

You may not qualify if:

• Presence of additional systemic, rheumatologic, or metabolic diseases that could affect bone metabolism, other than melorheostosis.
• Presence of cardiovascular, pulmonary, or neurological disease at a level that may restrict exercising.
• History of surgical intervention or severe trauma within the last six months.
• Presence of psychiatric or cognitive disorders that could interfere with evaluation and exercise applications.
• Failure to continue the 8-week exercise program.

Sponsors & Collaborators

• Yeditepe University: lead

Study Sites (1)

Yeditepe University

Istanbul, 34755, Turkey (Türkiye)

Location

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MeSH Terms

Conditions

Melorheostosis; Motor Activity

Condition Hierarchy (Ancestors)

Osteosclerosis; Osteochondrodysplasias; Bone Diseases, Developmental; Bone Diseases; Musculoskeletal Diseases; Behavior

Study Officials

• Aslı Yeral, Asst. Prof. Dr.

  Yeditepe University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 16, 2026
• First Posted: April 9, 2026
• Study Start: April 18, 2026
• Primary Completion: May 19, 2026
• Study Completion (Estimated): September 22, 2026
• Last Updated: June 26, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)