Neural Synchronization During Gesture Production and Comprehension in Individuals With Aphasia and Healthy Controls: A Study Using EEG Hyperscanning

NCT07518563 | Completed DMC

• 2 other identifiers: 2021.23Ethical Committee Veneto
• Study Type: observational
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

This study explores the neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, neural coupling between the encoder (PWA) and decoder (healthy participant) was analyzed during tasks involving social, affective, and informative gestures with both positive and negative emotional valence.

Conditions

Aphasia; Gestures; Stroke

Keywords

gestures; aphasia; EEG; hyperscanning

Outcome Measures

Primary Outcomes (1)

• neural synchronization

  Neural synchronization between encoder and decoder Description: Synchronization of activity in the alpha, beta, delta, and theta EEG bands between the encoder and decoder, assessed during task performance. Metrics will be reported separately for each frequency band. Time Frame: At EEG recording

  during EEG hyperscanning recording

Study Arms (1)

Person with Aphasia

Behavioral: Person with Aphasia

Interventions

Person with Aphasia BEHAVIORAL

EEG during gestures production

Person with Aphasia

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Person with Aphasia due to left stroke

You may qualify if:

• Age ≥ 18 years Diagnosis of left-sided stroke Clinical diagnosis of aphasia Native language: Italian (L1 Italian)

You may not qualify if:

• History of psychiatric disorders

Sponsors & Collaborators

• IRCCS San Camillo, Venezia, Italy: lead

Study Sites (1)

Sara Nordio

Venice-Lido, Italy

Location

MeSH Terms

Conditions

Aphasia; Stroke; Gestures

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Kinesics; Nonverbal Communication; Communication; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: March 25, 2026
• First Posted: April 8, 2026
• Study Start: June 1, 2022
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2023
• Last Updated: April 22, 2026

Record last verified: 2026-04

Locations

IT (1)