Factors Influencing Subjective Visual Quality in Human Eyes

NCT07518316 | Not Yet Recruiting

• 1 other identifier: KY-2025032
• Study Type: interventional
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

To assess subjective visual symptoms using the QoV questionnaire, measure pupil size using the Atongmu Pupillometer, measure wavefront aberrations using the OPD-Scan III Aberrometer, and measure/calculate the effective optical zone using the Pentacam system. The relationships between pupil size, higher-order aberrations (HOAs), effective optical zone after refractive surgery, and subjective visual symptoms will be explored.

Conditions

Corneal Wavefront Aberration; Refractive Errors

Outcome Measures

Primary Outcomes (6)

• Total Higher-Order Aberrations (HOAs)

  Root mean square (RMS) of total higher-order aberrations measured using the OPD-Scan III. Units: micrometres (µm)

  3 months

• Effective Optical Zone Diameter

  Effective optical zone diameter measured using the Pentacam system. Units: millimetres (mm)

  3 months

• Central Corneal Thickness

  Central corneal thickness measured using the Pentacam system. Units: micrometres (µm)

  3 months

• Coma Aberration (RMS)

  Coma aberration (root mean square) measured using the OPD-Scan III. Units: micrometres (µm)

  3 months

• Trefoil Aberration (RMS)

  Trefoil aberration (root mean square) measured using the OPD-Scan III. Units: micrometres (µm)

  3 months

• Spherical Aberration (Zernike Z₄⁰, RMS)

  Spherical aberration expressed as Zernike coefficient Z₄⁰ (RMS), measured using the OPD-Scan III. Units: micrometres (µm)

  3 months

Study Arms (1)

Corneal refractive surgery

EXPERIMENTAL

Corneal refractive surgery aims to correct refractive errors by altering the shape of the anterior surface of the cornea or by changing its refractive properties.

Procedure: Corneal Refractive Surgery

Interventions

Corneal Refractive Surgery PROCEDURE

Corneal refractive surgery aims to correct refractive errors by altering the shape of the anterior surface of the cornea or by changing its refractive properties.

Corneal refractive surgery

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Myopic or myopic astigmatism patients aged 18 to 45 years.
• Transparent ocular media, absence of ocular diseases such as corneal leucoma, cataract, etc.
• Round pupils with normal light reflex, absence of dyscoria, corectopia, significant persistent pupillary membrane, or absence of the pupil.
• Absence of severe psychological or psychiatric disorders, ability to cooperate with examinations and questionnaire completion.
• Subject agrees to participate in this clinical study and cooperate with examinations and related procedures.

You may not qualify if:

• Opacities of the ocular media, such as corneal leucoma, cataract, etc.
• Pupil deformation, displacement, significant persistent pupillary membrane, or absence of the pupil.
• Severe psychological or psychiatric disorders.
• Concurrent diagnosis of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis, etc.).
• History of ocular surgery or trauma.
• Nystagmus or inability to cooperate.

Sponsors & Collaborators

• Tianjin Eye Hospital: lead

MeSH Terms

Conditions

Corneal Wavefront Aberration; Refractive Errors

Condition Hierarchy (Ancestors)

Corneal Diseases; Eye Diseases

Central Study Contacts

Yan Wang

CONTACT

86-13602089393; wangyan7143@vip.sina.com

Shufan Wang

CONTACT

86-13376966029; wangshufan2049@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2025
• First Posted: April 8, 2026
• Study Start: March 18, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: April 8, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share