Light and Anesthesia

NCT07517484 | Recruiting

• 1 other identifier: 2025-h018
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include: Does light condition affect the dosage of anesthetic medications during anesthesia? By what mechanism does light exposure exert an influence on anesthesia? Participants will be randomly allocated to either the light-shielded group or the non-light-shielded group.Patients in the light-shielded group will wear an eye shield during anesthesia. The following data will be recorded for all patients: Induction drug dosage Induction time Intraoperative anesthetic dosage Emergence time

Conditions

Light; Anesthesia; Sedation

Keywords

light; anesthesia; sedation depth

Outcome Measures

Primary Outcomes (1)

• The dose of sedative medications

  The dose of sedative medications required during the induction period in patients

  Perioperative

Secondary Outcomes (3)

• Induction time of anesthesia

  Perioperative

• total dose of sedative medications

  during surgery

• emergence time

  Perioperative

Study Arms (2)

the light-shielded group

EXPERIMENTAL

Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.

Device: eye mask

the non-light-shielded group

NO INTERVENTION

Interventions

eye mask DEVICE

Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.

the light-shielded group

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• a. Age between 18 and 65 years, regardless of gender;
• b. ASA physical status I-II;
• c. 18.5 ≤ BMI ≤ 28;
• d. Signed written informed consent.

You may not qualify if:

• a. Blindness or history of photosensitivity disorders;
• b. Patients requiring medication for sleep, or with a history of sleep disorders;
• c. Presence of neurological diseases;
• d. Pregnancy;
• e. Severe hepatic or renal dysfunction;
• f. History of anesthetic drug abuse or alcohol abuse;
• g. History of adverse anesthesia events (difficult airway, allergy to anesthetic agents).

Sponsors & Collaborators

• Peking University People's Hospital: lead

Study Sites (1)

Peking University People's Hospital

Beijing, 100044, China

RECRUITING

Related Publications (16)

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  PMID: 32807382 BACKGROUND

• Shao Y, Li Y, Wang N, Xue Y, Wang T, Qiu F, Lu Y, Lan D, Wu H. Effect of daily light exposure on sleep in polar regions: A meta-analysis. J Sleep Res. 2024 Oct;33(5):e14144. doi: 10.1111/jsr.14144. Epub 2024 Jan 22.

  PMID: 38253963 BACKGROUND

• Ishizawa M, Uchiumi T, Takahata M, Yamaki M, Sato T. Effects of pre-bedtime blue-light exposure on ratio of deep sleep in healthy young men. Sleep Med. 2021 Aug;84:303-307. doi: 10.1016/j.sleep.2021.05.046. Epub 2021 Jun 8.

  PMID: 34217920 BACKGROUND

• Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption. Life Sci. 2017 Mar 15;173:94-106. doi: 10.1016/j.lfs.2017.02.008. Epub 2017 Feb 16.

  PMID: 28214594 BACKGROUND

• Barger LK, Sullivan JP, Lockley SW, Czeisler CA. Exposure to Short Wavelength-Enriched White Light and Exercise Improves Alertness and Performance in Operational NASA Flight Controllers Working Overnight Shifts. J Occup Environ Med. 2021 Feb 1;63(2):111-118. doi: 10.1097/JOM.0000000000002054.

  PMID: 33065729 BACKGROUND

• Daurat A, Foret J, Benoit O, Mauco G. Bright light during nighttime: effects on the circadian regulation of alertness and performance. Biol Signals Recept. 2000 Nov-Dec;9(6):309-18. doi: 10.1159/000014654.

  PMID: 11025337 BACKGROUND

• Dollish HK, Tsyglakova M, McClung CA. Circadian rhythms and mood disorders: Time to see the light. Neuron. 2024 Jan 3;112(1):25-40. doi: 10.1016/j.neuron.2023.09.023. Epub 2023 Oct 18.

  PMID: 37858331 BACKGROUND

• LeGates TA, Fernandez DC, Hattar S. Light as a central modulator of circadian rhythms, sleep and affect. Nat Rev Neurosci. 2014 Jul;15(7):443-54. doi: 10.1038/nrn3743. Epub 2014 Jun 11.

  PMID: 24917305 BACKGROUND

• Ramsey DJ, Ramsey KM, Vavvas DG. Genetic advances in ophthalmology: the role of melanopsin-expressing, intrinsically photosensitive retinal ganglion cells in the circadian organization of the visual system. Semin Ophthalmol. 2013 Sep-Nov;28(5-6):406-21. doi: 10.3109/08820538.2013.825294. Epub 2013 Sep 6.

  PMID: 24010846 BACKGROUND

• Jensen EW, Litvan H, Struys M, Martinez Vazquez P. Pitfalls and challenges when assessing the depth of hypnosis during general anaesthesia by clinical signs and electronic indices. Acta Anaesthesiol Scand. 2004 Nov;48(10):1260-7. doi: 10.1111/j.1399-6576.2004.00521.x.

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  PMID: 23962378 BACKGROUND

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  PMID: 16751211 BACKGROUND

Central Study Contacts

Yi Feng, Ph.D

CONTACT

010-88325590; doctor_yifeng@sina.com

Xiaoyan Li, Ph.D

CONTACT

18810599681; 2411110461@bjmu.edu.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Data analyst
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief of Anesthesiology

Study Record Dates

• First Submitted: March 26, 2026
• First Posted: April 8, 2026
• Study Start: October 3, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: May 29, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)