Adductor Canal Block Combined With Local Infiltration Analgesia vs Local Infiltration Analgesia Alone for Postoperative Pain in Total Knee Arthroplasty

NCT07517159 | Completed

• 1 other identifier: 08-349-25
• Study Type: interventional
• Target: 61
• Locations: 1 country
• Sites: 1

Brief Summary

Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, which may impair early mobilization and functional recovery. Multimodal analgesia techniques are widely used to improve postoperative pain control while minimizing opioid consumption. Local infiltration analgesia (LIA) is a commonly used method; however, its effectiveness may be limited when used alone. The adductor canal block (ACB) provides effective analgesia while preserving quadriceps muscle strength. This prospective randomized controlled study aims to compare the effectiveness of adductor canal block combined with local infiltration analgesia versus local infiltration analgesia alone on postoperative pain scores in patients undergoing total knee arthroplasty. The primary outcome is postoperative pain assessed using the NRS at multiple time points within the first 48 hours. Secondary outcomes include opioid consumption, functional recovery parameters and hemodynamic parameters. The results of this study are expected to contribute to optimizing postoperative analgesia strategies in total knee arthroplasty.

Conditions

Osteoarthritis, Knee

Keywords

Adductor Canal Block; Local Infiltration Analgesia; Total Knee Arthroplasty; Postoperative Pain; Multimodal Analgesia; NRS; Hemodynamic

Outcome Measures

Primary Outcomes (1)

• Postoperative pain at rest (Numerating Rating Scale, NRS)

  Postoperative pain was assessed using the NRS at rest at predefined time points. Postoperative pain was assessed using the Numeric Rating Scale (NRS), ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Pain scores were recorded at rest at predefined time points.

  2,6,12,24,48

Secondary Outcomes (4)

• Opioid Consumption

  0-48 hours postoperatively

• Knee flexion range of motion (degrees) measured with a goniometer

  24 and 48 hours postoperatively

• Heart rate (beats per minute)

  Baseline (preoperative) and every 15 minutes from induction of anesthesia to extubation

• Mean arterial pressure (mmHg)

  Baseline (before induction of anesthesia) and every 15 minutes from induction of anesthesia to extubation

Study Arms (2)

ACB+LIA

EXPERIMENTAL

Patients in this group received an adductor canal block combined with local infiltration analgesia for postoperative pain management following total knee arthroplasty.

Procedure: Adductor Canal block; Procedure: Local Infiltration Analgesia

LIA

ACTIVE COMPARATOR

Patients in this group received local infiltration analgesia alone for postoperative pain management following total knee arthroplasty.

Procedure: Local Infiltration Analgesia

Interventions

Local Infiltration Analgesia PROCEDURE

Local infiltration analgesia was administered intraoperatively using local anesthetic agents around the surgical site.

ACB+LIA; LIA

Adductor Canal block PROCEDURE

Ultrasound-guided adductor canal block was performed using local anesthetic to provide postoperative analgesia.

ACB+LIA

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 18 years and older
• Patients scheduled for elective total knee arthroplasty
• American Society of Anesthesiologists (ASA) physical status I-III
• Patients who provided written informed consent

You may not qualify if:

• Known allergy to local anesthetics
• Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia
• Infection at the injection site
• Severe hepatic or renal dysfunction
• Neurological disorders affecting lower extremities
• Cognitive impairment preventing pain assessment
• Refusal to participate
• Body mass index (BMI) greater than 30 kg/m²

Sponsors & Collaborators

• Ankara University: lead

Study Sites (1)

Ankara University Faculty of Medicine, Ibni Sina Hospital

Ankara, Ankara, 06100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Pain, Postoperative

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician

Study Record Dates

• First Submitted: March 24, 2026
• First Posted: April 8, 2026
• Study Start: May 31, 2025
• Primary Completion: November 15, 2025
• Study Completion: November 15, 2025
• Last Updated: April 8, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)