Bilogical Assesment During Intrusion of Lower Incisors
Assessment of the Biological Response of the Corticision During Intrusion of Lower Incisors A Prospective Clinical Study
1 other identifier
interventional
16
0 countries
N/A
Brief Summary
biological assesment during intrusion of lower incisors
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2026
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 25, 2026
CompletedStudy Start
First participant enrolled
April 1, 2026
CompletedFirst Posted
Study publicly available on registry
April 7, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 1, 2027
May 5, 2026
April 1, 2026
1.1 years
March 25, 2026
May 4, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Gingival crevicular fluid (GCF) prostaglandin E2 (PGE2) levels measured by enzyme-linked immunosorbent assay (ELISA) (pg/mL)
GCF samples will be collected from lower incisors using microcapillary tubes at baseline and during follow-up visits. Prostaglandin E2 levels will be quantified using ELISA kits and expressed in pg/mL to assess the biological response to corticision-assisted intrusion.
12 weeks
Secondary Outcomes (2)
Amount of lower incisor intrusion measured in millimeters (mm) using cone beam computed tomography (CBCT)
12 weeks
External apical root resorption measured in millimeters (mm) using cone beam computed tomography (CBCT)
Time Frame: 12 weeks
Study Arms (2)
controlled
NO INTERVENTIONwithout corticision
active group
ACTIVE COMPARATORcorticision group
Interventions
1. Prior panoramic x-ray or serial periapical x-rays are essential to assure the availability of interradicular room to carry out the procedure. 2. Preoperative antiseptic mouthwash is administered to prevent potential infections. 3. Infiltration anesthesia is applied. 4. A reinforced 15T scalpel is positioned on the interradicular attached gingiva at an inclination of 45-60 degrees on the long axis of the tooth to be moved.
Eligibility Criteria
You may qualify if:
- Patients requiring extraction-based orthodontic treatment
- Presence of deep overbite requiring lower incisor intrusion
- Age range: 18-30 years
- Good general health
- Good oral hygiene
You may not qualify if:
- Systemic diseases affecting bone metabolism
- Previous orthodontic treatment
- Periodontal disease
- Smoking
- Pregnancy or lactation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Officials
- STUDY DIRECTOR
Ramadan Yu Abu-shahba, professor
Al-Azhar University, Faculty of Dental Medicine
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- postgraduate researcher
Study Record Dates
First Submitted
March 25, 2026
First Posted
April 7, 2026
Study Start
April 1, 2026
Primary Completion (Estimated)
May 1, 2027
Study Completion (Estimated)
August 1, 2027
Last Updated
May 5, 2026
Record last verified: 2026-04