Pronostic Factors in Elderly Patients Admitted to the Intensive Care Unit for Aneurysmal Subarachnoid Hemorrhage

NCT07508683 | Not Yet Recruiting

• 1 other identifier: 2025PI114
• Study Type: observational
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

Subarachnoid hemorrhage (SAH) represents a significant proportion of hemorrhagic strokes. Severe SAH in elderly patients is associated with poorer outcomes compared to younger cohorts. Better characterization of both short- and long -term prognosis in these patients is necessary to facilitate medical decision-making in the intensive care unit (ICU) Primary Objective: The primary objective is to identify prognostic factors associated with poor functional outcome or death at 6 months (± 2 months) in elderly patients admitted to the ICU for SAH. Secondary Objectives: To evaluate in-hospital mortality among elderly patients admitted to the ICU for SAH. To describe the causes of in-hospital death (brain death, withholding/withdrawal of life-sustaining treatment \[WOLST\], other medico-surgical causes) in elderly patients admitted to the ICU for SAH. To describe the care trajectory following hospital discharge for elderly patients admitted to the ICU for SAH. To evaluate the mean length of stay in the ICU and in the hospital (acute care) for elderly patients admitted to the ICU for SAH. To identify prognostic factors associated with poor functional outcome or death at 1 year in elderly patients admitted to the ICU for SAH.

Conditions

Subarachnoid Hemorrhage, Aneurysmal

Keywords

Subarachnoid Hemorrhage; Elderly; Prognostic Factors; Intensive Care Unit

Outcome Measures

Primary Outcomes (1)

• Modified Rankin Scale (MRS) et 6 months

  MRS : scale from 1(no symptoms) to 6 (dead) Good outcome : 0 - 2 Bad outcome: 3 - 6 The MRS grade is either collected if already available in the medical file or estimated retrospectively based on the patient neurological evaluation.

  6 months after ICU discharge

Secondary Outcomes (4)

• Intrahospital mortality

  Day 28

• Cause of intrahospital death

  Day 28

• Destination upon hospital discharge

  Day 28

• Modified Rankin Scale upon discharge from hospital.

  Day 28

Study Arms (1)

Elderly aneurysmal SAH patients hospitalized in ICU

Patients hospitalized in ICU for aneurysmal subarachnoid hemorrhage between Juin 30, 2021 and Juin 30, 2025. Aged 70 years or over the day of admission in ICU. In accordance with French regulations , the study included patients who did not object to the use of their clinical data after receiving written information.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients admitted in ICU for aneurysmal subarachnoid hemorrhage in 4 University Hospital Centers in France (CHU Nancy, CHU Reims, HC de Lyon, CHU Lille) between Juin 30, 2021 et Juin 30, 2025

You may qualify if:

• Patients hospitalized in ICU for aneurysmal subarachnoid hemorrhage
• Aged 70 years or over the day of admission in ICU
• Between Juin 30, 2021 and Juin 30, 2025

You may not qualify if:

• Decline to participate

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

Chru Nancy

Nancy, 54000, France

Location

MeSH Terms

Conditions

Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Viviane MARTIN, Chief of Research Departement

  CHRU NANCY, DRCI

  STUDY CHAIR

• Elodie JEANBERT, Methodologist, Statistician

  CHRU NANCY, DRCI

  STUDY CHAIR

Central Study Contacts

Ionel M ALB, MD Intensive Care/Anesthesia

CONTACT

0033-661028367; im.alb@chru-nancy.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator - MD Intensivist

Study Record Dates

• First Submitted: March 16, 2026
• First Posted: April 2, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: April 2, 2026

Record last verified: 2026-03

Locations

FR (1)