Effects of Exercise in Hemodialysis

NCT07507981 | Completed

• 1 other identifier: NMM-5123-24-25-1
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: To evaluate the effects of a six-month intradialytic aerobic exercise program on left ventricular ejection fraction in patients with end-stage kidney disease undergoing maintenance hemodialysis. Materials and Methods Design: Open-label, single-center, quasi-experimental, single-group study with pre- and post-intervention measurements. Study setting: the outpatient hemodialysis unit of the National Institute of Medical Sciences and Nutrition Salvador Zubirán. Participants: Patients aged ≥18 years with chronic kidney disease on hemodialysis for at least three months, who are at their dry weight. Procedures: An echocardiogram will be performed post-hemodialysis. Subsequently, patients will undergo a 30-minute intradialytic aerobic exercise program at submaximal intensity during the second hour of dialysis, three times per week for six months. At the end of the six-month period, a post-hemodialysis echocardiogram will be repeated.

Conditions

End Stage Cronic Kidney Disease; Hemodialysis

Keywords

Intradialytic Exercise; Hemodialysis; End Stage Cronic Kidney Disease

Outcome Measures

Primary Outcomes (1)

• Left ventricular ejection fraction

  Left ventricular ejection fraction measured by transthoracic echocardiogram

  From study enrollment to the initiation of the exercise program (within a maximum of 6 weeks), and subsequently from completion of the exercise program to up to 6 weeks thereafter

Study Arms (1)

Patients on hemodialysis who will perform intradialytic aerobic exercise

EXPERIMENTAL

Patients on hemodialysis who will perform intradialytic aerobic exercise for six months

Other: Intradialytic aerobic exercise program

Interventions

Intradialytic aerobic exercise program OTHER

A six-month intradialytic aerobic exercise program consisting of 30-minute sessions at submaximal intensity, performed during the second hour of hemodialysis three times per week.

Patients on hemodialysis who will perform intradialytic aerobic exercise

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged ≥18 years
• Receiving hemodialysis with a stable prescription for at least 3 months
• At their prescribed dry weight
• Provision of written informed consent

You may not qualify if:

• Active cardiovascular disease within the past 3 months
• Left ventricular ejection fraction \<40%
• Physical and/or cognitive impairment precluding exercise
• Blood pressure \>160/110 mmHg

Sponsors & Collaborators

• Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran: lead

Study Sites (1)

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Mexico City, 14080, Mexico

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Nephrologist

Study Record Dates

• First Submitted: March 23, 2026
• First Posted: April 2, 2026
• Study Start: May 1, 2025
• Primary Completion: February 28, 2026
• Study Completion: March 15, 2026
• Last Updated: April 2, 2026

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)