Decontamination Methods in the Treatment of Peri-implantitis
Treatment of Peri-implantitis by Air-polishing Abrasives and Antiseptics Solutions
1 other identifier
interventional
64
1 country
1
Brief Summary
The goal of this clinical study is to compare the effectiveness of different methods for decontaminating dental implant surfaces in the treatment of peri-implantitis. The main question it aims to answer is: Which combination of an antiseptic solution and an air-polishing powder is most effective for the non-surgical treatment of peri-implantitis? Researchers will compare three different treatment combinations (Miramistin with sodium bicarbonate, chlorhexidine with erythritol, and Octenisept with glycine) in patients diagnosed with peri-implantitis. Participants will receive the combined treatment at intervals of 7-10 days for one month. The study will assess changes in probing depth, bleeding, and bone loss at 1 and 2.5 months after treatment to determine the most effective and balanced approach for preserving implant surfaces and promoting tissue healing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Feb 2023
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 11, 2025
CompletedFirst Submitted
Initial submission to the registry
March 24, 2026
CompletedFirst Posted
Study publicly available on registry
March 30, 2026
CompletedMarch 30, 2026
March 1, 2026
2.8 years
March 24, 2026
March 24, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Probing Depth
Probing depth measured in millimeters using a graduated periodontal probe (UNC-15) at six sites per implant: mesiobuccal, buccal, distobuccal, mesiolingual, lingual, and distolingual. The mean probing depth per implant is calculated. A reduction in probing depth indicates treatment success.
Baseline, 1 month, and 2.5 months after start of treatment
Bleeding on Probing
Presence or absence of bleeding within 30 seconds after gentle probing at six sites per implant. The percentage of sites showing bleeding per implant is recorded. A decrease in bleeding on probing indicates improvement in peri-implant soft tissue health.
Baseline, 1 month, and 2.5 months after start of treatment
Secondary Outcomes (5)
Plaque Index
Baseline, 1 month, and 2.5 months after start of treatment
Gingival Index
Baseline, 1 month, and 2.5 months after start of treatment
Radiographic Bone Loss
Baseline and 2.5 months after start of treatment
Need for Surgical Intervention
From start of treatment through 2.5 months
Suppuration
Baseline, 1 month, and 2.5 months after start of treatment
Other Outcomes (1)
Safety / Adverse Events
From start of treatment through 2.5 months
Study Arms (3)
Miramistin + Sodium Bicarbonate
EXPERIMENTALParticipants in this arm receive non-surgical treatment for peri-implantitis using a combination of Miramistin antiseptic solution (0.01%) and air-polishing with sodium bicarbonate powder. The treatment is applied at intervals of 7-10 days for a total duration of one month.
Chlorhexidine + Erythritol
ACTIVE COMPARATORParticipants in this arm receive non-surgical treatment for peri-implantitis using a combination of Chlorhexidine antiseptic solution (0.05%) and air-polishing with erythritol powder. The treatment is applied at intervals of 7-10 days for a total duration of one month.
Octenisept + Glycine
ACTIVE COMPARATORParticipants in this arm receive non-surgical treatment for peri-implantitis using a combination of Octenisept antiseptic solution and air-polishing with glycine powder. The treatment is applied at intervals of 7-10 days for a total duration of one month.
Interventions
A non-surgical implant surface decontamination protocol combining a chemical antiseptic and a mechanical air-polishing abrasive. The intervention is applied in a clinical setting at intervals of 7-10 days for one month. First, the peri-implant pocket is irrigated with Miramistin solution (0.01%). Subsequently, the implant surface is treated with air-polishing using sodium bicarbonate powder directed at a 45-degree angle to remove the biofilm.
This is a non-surgical decontamination protocol for the treatment of peri-implantitis, combining a chemical antiseptic agent with a mechanical air-polishing abrasive. The treatment is applied in a clinical setting at intervals of 7-10 days over a total duration of one month. The procedure involves the application of an antiseptic solution (Chlorhexidine) to the affected peri-implant site, followed by mechanical debridement of the implant surface using air-polishing with a specific abrasive powder (\[Name of Powder\]). The abrasive flow is directed at a 45-degree angle to the implant surface to effectively disrupt and remove the bacterial biofilm. The goal of this combined approach is to achieve effective bacterial decontamination while preserving the integrity of the implant surface and minimizing cytotoxicity to surrounding tissues to promote healing.
This is a non-surgical decontamination protocol for the treatment of peri-implantitis, combining a chemical antiseptic agent with a mechanical air-polishing abrasive. The treatment is applied in a clinical setting at intervals of 7-10 days over a total duration of one month. The procedure involves the application of an antiseptic solution (Octenisept) to the affected peri-implant site, followed by mechanical debridement of the implant surface using air-polishing with a specific abrasive powder (Glycine). The abrasive flow is directed at a 45-degree angle to the implant surface to effectively disrupt and remove the bacterial biofilm. The goal of this combined approach is to achieve effective bacterial decontamination while preserving the integrity of the implant surface and minimizing cytotoxicity to surrounding tissues to promote healing.
Eligibility Criteria
You may qualify if:
- Age between 21 and 75 years Presence of at least one dental implant Diagnosis of peri-implantitis defined as probing depth ≥ 6 mm and radiographic bone loss ≥ 3 mm apical to the most coronal portion of the intraosseous part of the implant Ability to attend follow-up appointments for up to 3 months Willingness to participate and provide written informed consent
You may not qualify if:
- Presence of systemic diseases in a decompensated stage (e.g., uncontrolled diabetes mellitus, severe cardiovascular disease, psychotic disorders, active oncological disease) Current or prior use of immunosuppressive drugs, bisphosphonates, high-dose corticosteroids, antipsychotics, or other medications known to negatively affect peri-implant tissue regeneration and healing Pregnancy or lactation Unwillingness or inability to comply with study procedures Peri-implantitis requiring immediate surgical intervention or implant removal at baseline
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Pirogov Russian National Research Medical University
Moscow, 119021, Russia
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD candidate
Study Record Dates
First Submitted
March 24, 2026
First Posted
March 30, 2026
Study Start
February 1, 2023
Primary Completion
November 30, 2025
Study Completion
December 11, 2025
Last Updated
March 30, 2026
Record last verified: 2026-03