Cardiovascular Acoustics for Early Disease Detection

NCT07496775 | Not Yet Recruiting

• 1 other identifier: A097426
• Study Type: observational
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

There are many types of heart disease. Two of the most common causes are narrowings within the blood vessels that supply the heart (known as coronary artery disease), or valves within the heart becoming narrowed (stenosed) or leaky (regurgitation), known as heart valve disease. There are two main types of imaging used to test for these conditions. Coronary artery disease can be diagnosed by taking X-ray pictures of a dye when injected into the blood vessels. In some cases the dye is injected into the veins and a CT scanner is used (CT coronary angiography), in others the dye is injected via a tube placed in the artery (invasive coronary angiography). Valvular heart disease is normally diagnosed using an echocardiogram (ultrasound of the heart). In this study the investigators are looking for subtle changes in the sounds that come from the heart, which may allow heart disease to be detected earlier. The investigators are using a novel device, similar to a digital stethoscope, that has excellent sensitivity for heart sounds. Ultimately this may be used in community settings including GP surgeries, in this study the investigators are collecting sounds from patients undergoing routine scans as part of their workup for heart disease.

Conditions

Valvular Heart Disease; Coronary Artery Disease

Keywords

coronary artery disease; valvular heart disease; ischemic heart disease; cardiovascular acoustics; heart sounds; cardiac auscultation

Outcome Measures

Primary Outcomes (1)

• Discriminant score

  A discriminant score (minimum 0, maximum 1) for each of coronary artery disease and valvular heart disease will be generated by analysis of the phonographs.

  Investigations to be performed within six (6) months of one another.

Study Arms (4)

Control

No valvular heart disease, no coronary artery disease

Coronary artery disease

Significant coronary artery disease, no valvular heart disease

Valvular heart disease

Significant valvular heart disease, no coronary artery disease

Mixed disease

Significant coronary artery disease and significant valvular heart disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to Department of Cardiology, Cambridge University NHS Foundation Trust.

You may qualify if:

• Participants aged ≥18 years
• Able to provide written, informed consent
• Has undergone angiography in the previous 6 months and scheduled to undergo transthoracic echocardiography, or has undergone transthoracic echocardiography in the previous 6 months and scheduled to undergo angiography, or is scheduled to undergo transthoracic echocardiography and angiography within 6 months.
• Angiography and echocardiography performed within Cambridge University Hospitals NHS Foundation Trust.

You may not qualify if:

• Haemodynamic instability
• STEMI or high risk NSTEMI
• Anginal symptoms at rest
• Heart failure symptoms with NYHA 4
• Cardiovascular related admission or event occurring between imaging studies
• Uncontrolled symptomatic arrhythmia
• Acute pulmonary embolism
• Acute aortic dissection
• Previous valve intervention
• Suspected endocarditis

Sponsors & Collaborators

• Cambridge University Hospitals NHS Foundation Trust: lead
• University of Cambridge: collaborator

MeSH Terms

Conditions

Heart Valve Diseases; Coronary Artery Disease; Myocardial Ischemia

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Coronary Disease; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• James HF Rudd, PhD FRCP

  University of Cambridge

  PRINCIPAL INVESTIGATOR

• Jacob B Brubert, PhD MRCP

  Cambridge University NHS Foundation Trust

  STUDY DIRECTOR

Central Study Contacts

Stephen Kelleher

CONTACT

01223 217418; cuh.research@nhs.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Academic Clinical Fellow

Study Record Dates

• First Submitted: March 23, 2026
• First Posted: March 27, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 31, 2029
• Last Updated: April 1, 2026

Record last verified: 2026-03