Manual- VS Auto-Strain

NCT07496424 | Recruiting

• 1 other identifier: MUV EK 2416/2025
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Myocardial strain analysis provides additional and valuable information about left ventricular function, particularly in the perioperative setting with its dynamic changes in ventricular load conditions. This allows for earlier risk assessment and, if necessary, the initiation of faster and more targeted therapy. Unfortunately, conventional strain analysis using conventional methods currently takes approximately 5 minutes. However, this amount of time is often not available in a dynamically changing intraoperative setting during cardiac surgery. Therefore, the benefits of strain analysis have not yet been routinely utilized during the intraoperative course. However, new software solutions exist that can perform strain analysis fully automatically and reduce the examination time to a few seconds. However, it remains unclear whether these fully automated analyses also function reliably intraoperatively using transesophageal echocardiography (TEE). The aim of this study is to assess the reliability of these new methods.

Conditions

Transesophageal Echocardiography; Cardiac Anesthesia; Cardiac Surgery Patients

Outcome Measures

Primary Outcomes (1)

• Correlation between conventionally measured global longitudinal strain (GLS) and fully automated global longitudinal strain (Auto-GLS)

  1-3 days

Secondary Outcomes (1)

• Correlation between fully automated global longitudinal strain measured using GE EchoPac (GE-Auto-GLS) and fully automated global longitudinal strain measured using TOMTEC AutoStrain (TOMTEC Auto-GLS)

  1 day

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients undergoing cardiac surgery who are monitored with a transesophageal echocardiography probe

You may qualify if:

• Adult (≥18 years) cardiac surgery patients
• Sinus rhythm
• No severe valvular regurgitation
• Use of General Electric (GE) echocardiography systems (Vivid S60, S70, E95) and corresponding EchoPAC software as well as TOMTEC software.

You may not qualify if:

• Inadequate image quality
• Any severe heart valve regurgitation
• Mechanical circulatory support systems (e.g., LVAD, Impella, ECMO)

Sponsors & Collaborators

• Bruno Mora: lead

Study Sites (1)

General Hospital of Vienna - Medical University of Vienna

Vienna, 1090, Austria

RECRUITING

Central Study Contacts

Bruno Mora, Dr, MD, PhD

CONTACT

+4314040041090; bruno.mora@meduniwien.ac.at

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: March 22, 2026
• First Posted: March 27, 2026
• Study Start: March 23, 2026
• Primary Completion (Estimated): March 23, 2027
• Study Completion (Estimated): March 23, 2027
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)