Retrospective Study on Ventilator Weaning Outcomes in Patients With Acute Brain Injury

NCT07496125 | Withdrawn

• 1 other identifier: Retro WEAN ABI
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). However, prolonged exposure to IMV is consistently associated with an increased risk of ventilator-related complications and adverse outcomes. Accordingly, alongside the initiation of IMV, timely and safe liberation from ventilator should be considered. Nevertheless, data detailing the weaning process and its associated outcomes in mechanically ventilated patients with ABI remain scarce. To address this gap, the investigators conducted an observational study aimed at characterizing the ventilator weaning process and outcomes in patients with ABI receiving IMV, using the modified WIND classification.

Conditions

Acute Brain Injuries; Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• weaning outcome

  The primary endpoint was the weaning outcome according to the modified WIND classification

  day 90

Study Arms (1)

Classified by weaning outcomes

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with ABI including traumatic brain injury (TBI), non-traumatic intracranial hemorrhage (ICH), subarachnoid aneurysmal hemorrhage (SAH), acute ischemic stroke (AIS), and central nervous system infection were eligible to this study, if they were ≥ 18 years old and underwent IMV for at least 24 hours

You may qualify if:

• Patients with ABI
• ≥ 18 years old
• underwent IMV for at least 24 hours

You may not qualify if:

• already tracheostomized
• concurrent of cervical spinal cord injury
• pregnant or lactation
• withdraw of life-sustaining treatment within the first 24 hours of ICU admission

Sponsors & Collaborators

• Southeast University, China: lead

Study Sites (1)

Department of Critical Care Medicine, Zhongda Hospital

Nanjing, Jiangsu, 210009, China

Location

MeSH Terms

Conditions

Brain Injuries

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD & MD

Study Record Dates

• First Submitted: March 22, 2026
• First Posted: March 27, 2026
• Study Start: January 1, 2018
• Primary Completion: December 31, 2025
• Study Completion: March 1, 2026
• Last Updated: June 8, 2026

Record last verified: 2026-06

Locations

CN (1)