Analgesic Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Posterior Transversus Abdominis Plane Block in Patients Undergoing Open Nephrectomy

NCT06892743 | Recruiting

• 1 other identifier: MS-389-2024
• Study Type: interventional
• Target: 56
• Locations: 1 country
• Sites: 2

Brief Summary

Renal cell carcinoma (RCC) accounts for 2-3% of all cancers and is a common malignancy of the genitourinary tract. Open nephrectomy, performed through midline, subcostal, or flank incisions, remains a standard treatment but often results in significant postoperative pain, leading to respiratory muscle dysfunction, increased pulmonary complications, and prolonged hospital stays. Acute surgical pain arises from inflammatory responses, activation of spinal pain pathways, and muscle spasms. While postoperative pain typically improves during recovery, some patients develop chronic postsurgical pain (CPSP), lasting at least two months postoperatively. Opioids and epidural analgesia are commonly used for pain control, but their side effects and invasiveness necessitate safer, effective alternatives. Ultrasound (US)-guided peripheral nerve and field blocks have become integral to multimodal analgesia. One such technique, the \*\*external oblique intercostal plane block (EOIPB)\*\*, was introduced as a modification of fascial plane blocks, targeting anterior and lateral cutaneous nerves (T6-T10). EOIPB offers advantages over quadratus lumborum block (QLB) and erector spinae plane block (ESPB) by being performed in the supine position and providing superior midline analgesia compared to serratus intercostal plane block (SIPB). Similarly, the transversus abdominis plane (TAP) block, particularly the posterior approach, delivers analgesia from T7 to T12 by anesthetizing anterior and lateral cutaneous nerve branches. While case series suggest EOIPB may be effective for post-nephrectomy pain, comparative studies between EOIPB and posterior TAP block in open nephrectomy: Aim of the Study: To evaluate the postoperative analgesic effects of posterior transversus abdominis plane (TAP) block and external oblique intercostal plane block (EOIPB) in patients undergoing open nephrectomy under general anesthesia.

Conditions

Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• Postoperative morphine consumption (mg) in the first 24 hrs .

  Time elapsed from the end of the block procedure till the end of the 24 hours postoperatively

Study Arms (2)

EOIPB-Group

ACTIVE COMPARATOR

Procedure: US-guided external oblique intercostal plane block (EOIPB)

Posterior TAP - Group

ACTIVE COMPARATOR

Procedure: US-guided external oblique intercostal plane block (EOIPB)

Interventions

US-guided external oblique intercostal plane block (EOIPB) PROCEDURE

US Guided external oblique intercostal plane block (EOIPB) or Posterior TAP Block:

Also known as: US Guided Posterior TAP Block:

EOIPB-Group; Posterior TAP - Group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients whom diagnosed as having renal carcinoma and scheduled for open nephrectomy under general anesthesia.
• ASA class II- III.
• Age ≥ 18 and ≤ 65 years.
• Body mass index (BMI) less than 40kg/m2.

You may not qualify if:

• \. Patient refusal. 2. Hepatic and renal insufficiency. 3. Unstable cardiovascular or pulmonary disease. 4. History of psychiatric and cognitive disorders. 5. Patients with known sensitivity or contraindications to the drug used. 6. Patients on regular opioid consumption.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (2)

Abeer Ahmed Mohamed

Maadi, Cairo Governorate, 11728, Egypt

RECRUITING

Kasr Alainy Faculty of Medicine - Cairo university

Cairo, 00225, Egypt

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Central Study Contacts

Abeer A Mohamed

CONTACT

01005244590; abeer_ahmed@kasralainy.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 9, 2025
• First Posted: March 25, 2025
• Study Start: April 1, 2025
• Primary Completion: October 1, 2025
• Study Completion: December 1, 2025
• Last Updated: March 25, 2025

Record last verified: 2025-03

Locations

EG (2)