NCT07495241

Brief Summary

A carotid web (CaW) is a shelf-like, thin, triangular endoluminal projection typically arising from the posterior wall of the internal carotid artery (ICA) bulb. CaW is considered by many to be an intimal variant of fibromuscular dysplasia and is associated with an increased risk of ischemic stroke in otherwise low-risk, younger patients. The CaWY study is a cross-sectional, multicenter, population-based sonographic survey with blinded central image adjudication, reported in accordance with STROBE guidelines for cross-sectional studies, aimed at estimating the prevalence of CaW detected by duplex sonography in the general population aged 15-25 years.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
829

participants targeted

Target at P75+ for all trials

Timeline
7mo left

Started Jan 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress50%
Jan 2026Feb 2027

Study Start

First participant enrolled

January 4, 2026

Completed
7 days until next milestone

First Submitted

Initial submission to the registry

January 11, 2026

Completed
3 months until next milestone

First Posted

Study publicly available on registry

March 27, 2026

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2027

Last Updated

March 27, 2026

Status Verified

March 1, 2026

Enrollment Period

12 months

First QC Date

January 11, 2026

Last Update Submit

March 22, 2026

Conditions

Carotid Web

Keywords

PrevalenceCarotid arteryCarotid webDuplex sonography

Outcome Measures

Primary Outcomes (1)

  • Prevalence

    Prevalence of web in youth population

    on the day of the ultrasound examination

Study Arms (1)

Youth

Age 15 - 25 years

Eligibility Criteria

Age15 Years - 25 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodProbability Sample
Study Population

General population aged 15 - 25 years

You may qualify if:

  • Male or female
  • Age 15 - 25 years at enrollment
  • Able to provide informed consent

You may not qualify if:

  • Prior carotid endarterectomy and/or angioplasty and stenting
  • Neck irradiation
  • Known vasculopathy with non-web lesions that preclude assessment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Medicine, University of Ostrava

Ostrava, Moravskoslezský kraj, 70300, Czechia

RECRUITING

Related Publications (5)

  • Yang J, Zhou F, Lei N, Liu R, Yang B, Zhang T, Li X, Xing Y. Carotid web ultrasonography and its associations with ischemic stroke: a preliminary observational study. BMC Neurol. 2025 Dec 3;26(1):18. doi: 10.1186/s12883-025-04486-w.

    PMID: 41340049RESULT

  • Talathi S, Lipsitz EC. Current Therapy for Carotid Webs. Ann Vasc Surg. 2025 Apr;113:415-420. doi: 10.1016/j.avsg.2024.08.014. Epub 2024 Oct 16.

    PMID: 39424178RESULT

  • Yang T, Yoshida K, Maki T, Fushimi Y, Yamada K, Okawa M, Yamamoto Y, Takayama N, Suzuki K, Miyamoto S. Prevalence and site of predilection of carotid webs focusing on symptomatic and asymptomatic Japanese patients. J Neurosurg. 2021 Mar 5;135(5):1370-1376. doi: 10.3171/2020.8.JNS201727. Print 2021 Nov 1.

    PMID: 33668027RESULT

  • Chen H, Colasurdo M, Costa M, Nossek E, Kan P. Carotid webs: a review of pathophysiology, diagnostic findings, and treatment options. J Neurointerv Surg. 2024 Nov 22;16(12):1294-1298. doi: 10.1136/jnis-2023-021243.

    PMID: 38290814RESULT

  • Fontaine L, Guidolin B, Viguier A, Gollion C, Barbieux M, Larrue V. Ultrasound characteristics of carotid web. J Neuroimaging. 2022 Sep;32(5):894-901. doi: 10.1111/jon.13022. Epub 2022 Jul 10.

    PMID: 35811446RESULT

Study Officials

  • David Školoudík, Prof., M.D., Ph.D.

    University of Ostrava

    PRINCIPAL INVESTIGATOR

Central Study Contacts

David Školoudík, Prof., M.D., Ph.D.

CONTACT

+420-739782970skoloudik@email.cz

David Pakizer, MSc., Ph.D.

CONTACT

+420-776457295david.pakizer@email.cz

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Neurology

Study Record Dates

First Submitted

January 11, 2026

First Posted

March 27, 2026

Study Start

January 4, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

February 28, 2027

Last Updated

March 27, 2026

Record last verified: 2026-03

Locations

CZ(1)