Treatment Response in Patients With Medication-Overuse Headache

NCT07487649 | Recruiting

• 1 other identifier: 29/12/2025-Number:13/8
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study to evaluate pre-injection patient-related factors that may influence treatment response in patients with medication-overuse headache who underwent ultrasound-guided greater occipital nerve block.

Conditions

Medication-overuse Headache; Treatment; Headache; Greater Occipital Nerve Block

Outcome Measures

Primary Outcomes (1)

• the number of days of analgesic use for headache

  Patients will be questioned the total number of days on which they used analgesics for headache during the past month.

  Baseline

Secondary Outcomes (6)

• Headache severity

  Baseline

• Post-injection pain severity

  Baseline

• Headache-related disability

  Baseline

• Pressure pain threshold

  Baseline

• Anxiety and depression levels

  Baseline

Study Arms (2)

Treatment success group

Patients who demonstrated a ≥50% reduction in the number of days of analgesic use for headache at the end of the second-month evaluation

Other: Treatment outcome

Treatment failure group

Patients who demonstrated a \<50% reduction in the number of days of analgesic use for headache at the end of the second-month evaluation

Other: Treatment outcome

Interventions

Treatment outcome OTHER

Before the injection, patients will be evaluated for the number of headache days, headache severity, the number of days of analgesic use for headache, headache-related disability, pressure pain threshold over the bilateral greater occipital nerve, anxiety and depression scores, and sleep quality. At 1 and 2 months after the injection, they will be reassessed for the number of headache days, headache severity, and the number of days of analgesic use for headache. In addition, at 1 hour after the injection, the pain experienced during the injection procedure will be assessed.

Treatment failure group; Treatment success group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent ultrasound-guided greater occipital nerve block with a diagnosis of medication-overuse headache at Edirne Sultan 1. Murat State Hospital

You may qualify if:

• Age between 18 and 65 years
• Diagnosis of medication-overuse headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)
• Diagnosis of medication-overuse headache associated with the use of triptans or nonsteroidal anti-inflammatory drugs
• Previous diagnosis of chronic migraine or chronic tension-type headache according to the ICHD-3 criteria

You may not qualify if:

• History of severe head or neck trauma or previous neurosurgical intervention
• Presence of a severe psychiatric disorder (e.g., severe depression, schizophrenia)
• History of infectious disease, chronic inflammatory disease, or malignancy
• Previous diagnosis of secondary headache
• History of substance abuse
• Pregnancy or breastfeeding
• History of an additional neurological disorder (e.g., cerebrovascular disease, multiple sclerosis)
• Difficulty with cooperation
• Presence of a concomitant systemic disease that may affect quality of life (e.g., congestive heart failure, chronic kidney disease, chronic liver disease, pulmonary disease, uncontrolled diabetes, or peripheral vascular disease)

Sponsors & Collaborators

• Sultan 1. Murat State Hospital: lead

Study Sites (1)

Sultan 1. Murat State Hospital

Edirne, 22030, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Headache Disorders, Secondary; Headache

Interventions

Treatment Outcome

Condition Hierarchy (Ancestors)

Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Prognosis; Diagnosis; Outcome Assessment, Health Care; Outcome and Process Assessment, Health Care; Quality of Health Care; Health Services Administration; Health Care Evaluation Mechanisms; Health Care Quality, Access, and Evaluation

Central Study Contacts

Alper Mengi, MD

CONTACT

+90 537 651 03 85; dralpmengi@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 17, 2026
• First Posted: March 23, 2026
• Study Start: March 17, 2026
• Primary Completion: May 30, 2026
• Study Completion: May 30, 2026
• Last Updated: March 23, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)