Effectiveness of Nurse-Led Interventions on Respiratory Outcomes in Hospitalized Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT07484178 | Not Yet Recruiting DMC

• 1 other identifier: UHS/DPS-26/575
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate whether respiratory nursing interventions can improve respiratory outcomes in patients hospitalized with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are: Do respiratory nursing interventions improve dyspnea levels measured by the Modified Medical Research Council (mMRC) Dyspnea Scale? Do these interventions improve oxygen saturation and pulmonary function (FVC, FEV1, and FEV1/FVC ratio)? Researchers will compare patients receiving respiratory nursing interventions plus routine hospital care with patients receiving routine hospital care alone to determine whether the interventions improve respiratory outcomes. Participants will: Undergo baseline assessment using the mMRC Dyspnea Scale, pulse oximetry, and pulmonary function tests. Receive either respiratory nursing interventions (deep breathing exercises, chest percussion, postural drainage, and lukewarm water intake) along with routine care or routine hospital care alone. Be reassessed after the intervention period using the same respiratory outcome measures.

Conditions

Acute Exacerbation Copd

Keywords

Nursing Intervention; COPD; Acute Exacerbation; Respiratory outcomes

Outcome Measures

Primary Outcomes (2)

• Change in Dyspnea Severity

  Change in dyspnea severity measured using the Modified Medical Research Council Dyspnea Scale to assess the dyspnea affecting functioning in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease. 0-5 Scale (0 Minimal functioning impairment and 4 maximum functioning impairment)

  Baseline to Day 4 of hospitalization or at discharge if earlier.

• Change in Pulmonary Function

  Change in pulmonary function parameters including Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), and FEV1/FVC ratio measured using pulmonary function tests to determine the impact of respiratory nursing interventions in COPD patients with acute exacerbation. Normal is greater than 70%. Less than 70% means decreased pulmonary function.

  Baseline to Day 4 of hospitalization or at discharge if earlier.

Secondary Outcomes (1)

• Change in Oxygen Saturation (SpO₂)

  Baseline to Day 4 of hospitalization or at discharge if earlier.

Study Arms (2)

Control Arm

NO INTERVENTION

Control arm will receive standard care only.

Experimental Group will receive nursing intervention

EXPERIMENTAL

Experimental Group will receive nursing interventions such as deep breathing exercise, chest percussions, postural drainage and lukewarm water intake along with standard care

Other: Experimental group will receive nursing interventions such as deep breathing exercise, chest percussions along with standard care.

Interventions

Experimental group will receive nursing interventions such as deep breathing exercise, chest percussions along with standard care. OTHER

The intervention consists of a structured package of respiratory nursing interventions provided in addition to routine hospital care for patients hospitalized with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD). It includes deep breathing exercises, chest percussion, postural drainage, and lukewarm water intake, administered by trained nursing staff according to a standardized protocol during hospitalization. These combined interventions aim to enhance airway clearance, improve ventilation, and reduce mucus viscosity, thereby improving dyspnea, oxygen saturation, and pulmonary function outcomes. The integration of multiple respiratory nursing techniques as an add-on to routine care distinguishes this intervention from standard management practices.

Experimental Group will receive nursing intervention

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed cases of COPD admitted for acute exacerbation according to Global Initiative for Chronic Obstructive Lung Disease.
• Adults aged \> 40 years (WHO, 2023; GOLD, 2024).
• Both genders (male \& female).
• Hemodynamically stable at the time of enrollment in terms of vital signs (e.g., blood pressure \> 90/60 mmHg, heart rate between 60-100 bpm) to safely undergo nursing interventions without acute risk (Jarhyan et al., 2021).
• Dyspnea Grade ≥ 2 on the mMRC Scale (Mahler and Wells, 1988).
• Blood Oxygen Saturation (SpO₂) ≥ 88% on Room Air or Oxygen Therapy (O'Driscoll, 2017).

You may not qualify if:

• Dyspnea due to cardio-pulmonary disease or other co-morbidities.
• Patients on mechanical ventilation and ICU admission.
• Patients with mental disorders.
• Patients with upper airway obstruction.

Sponsors & Collaborators

• University of Health Sciences Lahore: lead

Study Sites (1)

UHS

Lahore, Punjab Province, Pakistan

Location

Related Publications (1)

• Wu X, Zhang H, Chen J. Comprehensive expectoration nursing in elderly patients with pulmonary infection and its influence on respiratory function. Am J Transl Res. 2021 Nov 15;13(11):12965-12972. eCollection 2021.

  PMID: 34956512 RESULT

Related Links

• Effect of Respiratory Rehabilitation Nursing Interventions on Acute Exacerbation Symptoms of Chronic Obstructive Pulmonary Disease Among Hospitalized Geriatric Patients
• Management of severe acute exacerbations of COPD: an updated narrative review

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Standard of Care

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Quality Indicators, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation

Study Officials

• Samina Kausar, Phd Nursing

  UHS

  STUDY DIRECTOR

Central Study Contacts

Misha Mazhar, MSN

CONTACT

+923026958223; mishamazhar786@gmail.com

Umar Iqbal, ACCA

CONTACT

+923009758649; umariqbal639@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MSN Student

Study Record Dates

• First Submitted: March 16, 2026
• First Posted: March 19, 2026
• Study Start: May 2, 2026
• Primary Completion (Estimated): August 15, 2026
• Study Completion (Estimated): October 20, 2026
• Last Updated: April 15, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)