Long-term Clinical Outcomes After Retinal Artery Occlusion

NCT07482228 | Recruiting

• 1 other identifier: CNUH-EXP-2026-013
• Study Type: observational
• Target: 15,000
• Locations: 1 country
• Sites: 1

Brief Summary

Retinal artery occlusion (RAO) is a rare but vision-threatening vascular disorder that is commonly caused by embolic events originating from the heart or carotid arteries. Patients with RAO are known to have an increased risk of subsequent cardiovascular and cerebrovascular events, including ischemic stroke and myocardial infarction. However, long-term outcomes and optimal medical treatment strategies for these patients remain insufficiently characterized. The purpose of this nationwide population-based study is to investigate the incidence of long-term cardiovascular and cerebrovascular outcomes in patients diagnosed with retinal artery occlusion using the Korean National Health Insurance Service (NHIS) database. In addition, the study aims to evaluate the impact of various medical therapies, including antiplatelet agents, anticoagulants, and statins, on long-term clinical outcomes.

Conditions

Retinal Artery Occlusion

Keywords

RAO; CRAO; BRAO

Outcome Measures

Primary Outcomes (1)

• Occurrence of MACCE

  major adverse cardiovascular and cerebrovascular event

  up to 5 years

Secondary Outcomes (8)

• Occurrence of all-cause death

  up to 5 years

• Occurrence of cardiac death

  up to 5 years

• Occurrence of myocardial infarction

  up to 5 years

• Occurrence of revascularization

  up to 5 years

• Occurrence of stroke

  up to 5 years

Study Arms (2)

Patients who underwent retinal artery occlusion

Among the total cohort, patients who underwent retinal artery occlusion were selected.

Other: retinal artery occlusion

Matched cohort

Among the total cohort, 1:6 age- and sex-matched subjects without retinal artery occlusion using a propensity score were generated.

Interventions

retinal artery occlusion OTHER

treatment for retinal artery occlusion

Patients who underwent retinal artery occlusion

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients newly diagnosed with retinal artery occlusion (RAO) between 2010 and 2024 identified from the Korean National Health Insurance Service (NHIS) database.

You may qualify if:

• Patients newly diagnosed with retinal artery occlusion

You may not qualify if:

• Patients with a prior diagnosis of retinal artery occlusion before the study period.
• Patients diagnosed with giant cell arteritis.

Sponsors & Collaborators

• Chonnam National University Hospital: lead

Study Sites (1)

Chonnam National University Hospital

Gwangju, Gwangju, 61469, South Korea

RECRUITING

MeSH Terms

Conditions

Retinal Artery Occlusion

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Seung Hun Lee, MD, PhD

  Chonnam National University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Seung Hun Lee, MD, PhD

CONTACT

82-62-220-6246; lsh8602@naver.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 16, 2026
• First Posted: March 19, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): August 31, 2027
• Last Updated: March 19, 2026

Record last verified: 2026-03

Locations

KR (1)