NCT02898480

Brief Summary

Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury. It remains unknown whether this can be used in retinal vascular occlusive diseases. The purpose of the present study is to examine whether the autoregulation of retinal vessel diameters in normal persons change after remote ischemic conditioning.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2016

Shorter than P25 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2016

Completed
7 days until next milestone

First Submitted

Initial submission to the registry

September 8, 2016

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 13, 2016

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 14, 2016

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2017

Completed
Last Updated

April 5, 2019

Status Verified

November 1, 2017

Enrollment Period

2 months

First QC Date

September 8, 2016

Last Update Submit

April 4, 2019

Conditions

Retinal Artery OcclusionRetinal Vein Occlusion

Outcome Measures

Primary Outcomes (1)

  • Diameter change of retinal vessel

    immediate

Study Arms (1)

Remote ischemic conditioning

EXPERIMENTAL
Procedure: Remote ischemic conditioning

Interventions

Remote ischemic conditioningPROCEDURE

Briefly reversible restricting of blood flow to upper limb in four cycles of 5 minutes of inflation at 200mm Hg followed by 5 minutes of deflation.

Remote ischemic conditioning

Eligibility Criteria

Age20 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Normal persons

You may not qualify if:

  • Present or previous eye disease
  • Use of medications except anti-conceptive
  • Epilepsy
  • Pregnancy or lactation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Retinal Artery OcclusionRetinal Vein Occlusion

Condition Hierarchy (Ancestors)

Retinal DiseasesEye DiseasesArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesVenous ThrombosisThrombosisEmbolism and Thrombosis

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 8, 2016

First Posted

September 13, 2016

Study Start

September 1, 2016

Primary Completion

November 14, 2016

Study Completion

May 1, 2017

Last Updated

April 5, 2019

Record last verified: 2017-11