Neuro-Emotional Release: Veins and Endocrine System (NERVE) Therapy for Children With Dysautonomia

NCT07481292 | Enrolling By Invitation

• 1 other identifier: EXPTP031326
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the feasibility of implementing an online assessment battery in tandem with normal \& customary complementary \& integrative healthcare (CIH) provided to children with dysautonomia. The secondary aim is to assess the potential impacts of CIH on clinical outcomes.

Conditions

Dysautonomia; Dysautonomia Like Disorder

Keywords

Dysautonomia; Pilot Projects; Pediatrics; Complementary Therapies

Outcome Measures

Primary Outcomes (4)

• Proportion of enrollees who are eligible to participate

  The number of enrollees (i.e., participants who consent) who score ≥20 on the baseline Pediatric Autonomic Symptom Scales (PASS), divided by the total number of enrollees. This assesses 'Eligibility'.

  From enrollment to baseline PASS submission (up to 48-hours)

• Proportion of participants complying with instructions

  The number of participants submitting online surveys within the 48-hour submission window, divided by the total number of participants. This assesses 'Compliance'

  From enrollment to the end of participation (up to 12 weeks)

• Proportion of participants adhering to the care plan

  The number of participants attending ≥90% of scheduled remote sessions with their CIH practitioner, divided by the total number of participants. This assesses 'Adherence'

  From enrollment to the end of participation (up to 12 weeks)

• Proportion of participants retained in the study

  The number of participants submitting the 4th and final online surveys, divided by the total number of participants. This assesses 'Retention'.

  From enrollment to the end of the 12 week study period

Secondary Outcomes (2)

• Change in Pediatric Autonomic Symptom Scales (PASS) scores

  Baseline; ~4 weeks; ~8 weeks; ~12 weeks

• Change in Short Sensory Profile (SSP) scores

  Baseline; ~4 weeks; ~8 weeks; ~12 weeks

Study Arms (1)

Children (5-12) with Dysautonomia

Children aged 5-14 years whose parents/caregivers identify the presence of symptoms associated with dysautonomia. A formal clinical diagnosis is not required for inclusion

Eligibility Criteria

• Age: 5 Years - 14 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children aged 5-14 years whose parents/caregivers identify the presence of symptoms associated with dysautonomia. A formal clinical diagnosis is not required for inclusion.

You may qualify if:

• years of age
• Baseline PASS score ≥20

You may not qualify if:

• History of epilepsy

Sponsors & Collaborators

• Life University: lead

Study Sites (1)

Integrated Holistic Wellness

Madina Town, Fsisalabad, 38000, Pakistan

Location

MeSH Terms

Conditions

Autonomic Nervous System Diseases; Dysautonomia like disorder

Condition Hierarchy (Ancestors)

Nervous System Diseases

Study Officials

• Tyson Perez, DC, PhD

  Life University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 4, 2026
• First Posted: March 18, 2026
• Study Start: March 14, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: March 20, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: (start date): within 1 year of study completion. (end date): indefinitely
• Access Criteria: IPD, metadata \& analytic code necessary to reproduce results will be made publicly accessible via a data repository

Locations

PA (1)