Association Between Intraoperative Mean Arterial Pressure Variability and Postoperative Fatigue in Patients Undergoing Laparoscopic Abdominal Surgery

NCT07481006 | Completed

• 1 other identifier: KY-20251111002
• Study Type: observational
• Target: 366
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective cohort study aims to investigate the relationship between intraoperative mean arterial pressure (MAP) variability and postoperative fatigue syndrome (POFS) in elderly patients (≥18 years) undergoing laparoscopic abdominal surgery. The main research question is: Does the degree of intraoperative MAP fluctuation correlate with postoperative fatigue in elderly patients? Eligible patients scheduled for elective laparoscopic abdominal surgery under general anesthesia will have their intraoperative blood pressure variability recorded (generalized average real variability, G-ARV), and postoperative fatigue and recovery will be assessed on postoperative days 1, 3, and 7 using the Christensen fatigue scale.

Conditions

Fatigue Symptom; Blood Pressure Variability

Outcome Measures

Primary Outcomes (1)

• Postoperative Fatigue (Christensen Score)

  Primary outcome is the patient's fatigue level measured using the Christensen fatigue scale on postoperative days 1, 3, and 7. This scale evaluates overall fatigue severity including physical exhaustion, muscle weakness, and attention deficits after laparoscopic abdominal surgery.

  Postoperative days 1, 3, and 7

Secondary Outcomes (2)

• Intraoperative Vasoactive Drug Use

  During surgery

• Postoperative Recovery Quality (QoR-15 Score)

  Postoperative days 1, 3, and 7

Study Arms (3)

Low MAP Variability (LV)

Patients are categorized based on intraoperative mean arterial pressure variability measured by generalized average real variability (G-ARV). The LV group includes patients with G-ARV ≤ 33rd percentile, the MV group includes patients with G-ARV between the 34th and 67th percentile, and the HV group includes patients with G-ARV \> 67th percentile. All patients undergo elective laparoscopic abdominal surgery under general anesthesia, and postoperative fatigue is assessed on days 1, 3, and 7 using the Christensen fatigue scale and QoR-15 questionnaire.

Medium MAP Variability (MV)

Patients are categorized based on intraoperative mean arterial pressure variability measured by generalized average real variability (G-ARV). The LV group includes patients with G-ARV ≤ 33rd percentile, the MV group includes patients with G-ARV between the 34th and 67th percentile, and the HV group includes patients with G-ARV \> 67th percentile. All patients undergo elective laparoscopic abdominal surgery under general anesthesia, and postoperative fatigue is assessed on days 1, 3, and 7 using the Christensen fatigue scale and QoR-15 questionnaire.

High MAP Variability (HV)

Patients are categorized based on intraoperative mean arterial pressure variability measured by generalized average real variability (G-ARV). The LV group includes patients with G-ARV ≤ 33rd percentile, the MV group includes patients with G-ARV between the 34th and 67th percentile, and the HV group includes patients with G-ARV \> 67th percentile. All patients undergo elective laparoscopic abdominal surgery under general anesthesia, and postoperative fatigue is assessed on days 1, 3, and 7 using the Christensen fatigue scale and QoR-15 questionnaire.

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes adult patients undergoing elective laparoscopic abdominal surgery at Lianyungang First People's Hospital. Participants will be monitored for intraoperative mean arterial pressure variability and postoperative fatigue. Patients must be capable of completing postoperative assessments on days 1, 3, and 7.

You may qualify if:

• Age ≥ 18 years;
• ASA physical status I-III;
• Scheduled for elective laparoscopic abdominal surgery under general anesthesia.

You may not qualify if:

• Severe cardiac, hepatic, or renal insufficiency, or major neurological or psychiatric disorders;
• Known allergy to drugs used during the study;
• Participation in other clinical trials within the past 3 months;
• Unable to complete the required questionnaires or assessments;
• Surgery duration \< 60 minutes.

Sponsors & Collaborators

• The First People's Hospital of Lianyungang: lead

Study Sites (1)

Lianyungang

Lianyungang, 博士, 222061, China

Location

MeSH Terms

Conditions

Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 14, 2026
• First Posted: March 18, 2026
• Study Start: April 15, 2026
• Primary Completion: June 30, 2026
• Study Completion: June 30, 2026
• Last Updated: July 7, 2026

Record last verified: 2026-07

Locations

CN (1)