Clinical Trial of Lactiplantibacillus Plantarum Dad-13 on Gut Microbiota Profile and Performance in Adolescent Athletes

NCT07476573 | Not Yet Recruiting DMC

• 3 other identifiers: KE/FK/0230/EC/2026Beasiswa Pendidikan IndonesiaFK-KMK
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this research is to analyze the effect of a Lactiplantibacillus plantarum Dad-13 supplementation on the gut microbiota profile and performance of adolescent athletes.

Conditions

Athlete; Probiotic; Performance; Gut Microbiota

Keywords

athlete; probiotic; performance; gut microbiota

Outcome Measures

Primary Outcomes (3)

• gut microbiota profile

  Gut microbiota profiles were measured from fecal samples, then isolated using 16S rDNA sequencing. Fecal samples were collected in the morning. Results: alfa and beta diversity

  From pre treatment and the end of treatment at 8 weeks

• Short chain fatty acid profile

  The total level or amount of short chain fatty acid metabolites produced from the fermentation process in the intestine obtained from feces. Results: Total amount of SCFA, acetic acid, propionic acid, butyric acid

  pre treatment and end of treatment at 8 weeks

• Physical Performance

  The physical performance measurement used was VO2max. The VO2max measurement method used a direct laboratory method with COSMED K5 before and after the intervention, with units of kg/mL.

  pre treatment and the end of treatment at 8 weeks

Secondary Outcomes (1)

• Fecal calprotectin concentration

  pre treatment and the end of treatment at 8 weeks

Study Arms (1)

Control group

EXPERIMENTAL

placebo capsule twice/day

Dietary Supplement: Probiotic Lactiplantibacillus plantarum Dad-13

Interventions

Probiotic Lactiplantibacillus plantarum Dad-13 DIETARY_SUPPLEMENT

Lactiplantibacillus plantarum Dad-13 is an indigenous probiotic strain isolated from the curd produced by spontaneous fermentation of buffalo milk in bamboo containers and originates from Minangkabau, West Sumatra, Indonesia.

Also known as: Dad-13

Control group

Eligibility Criteria

• Age: 12 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Residing in the BPPLOP dormitory of Central Java Province;
• Having a normal body mass index;
• Being an athlete in an endurance sport;
• Having no growth disorders

You may not qualify if:

• Injury, any health contraindication or failure to perform exercise procedures;
• Gastrointestinal infections, diseases, disorders;
• Past history of gastrointestinal surgery;
• Failure to follow the study protocol;
• Declared general feeling of being unwell

Sponsors & Collaborators

• Gadjah Mada University: lead

Study Sites (1)

Balai Pembinaan dan Pelatihan Olahraga Pelajar Provinsi Jawa Tengah

Semarang, Central Java, 50231, Indonesia

Location

Central Study Contacts

Natalia Desy Putriningtyas, Dietisien., M.Gizi

CONTACT

+6285640885101; nataliadesyputriningtyas@mail.ugm.ac.id

Lilly Arsanti Lestari, Dr.

CONTACT

+62 877-3849-5045

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD student and as a Dietisien

Study Record Dates

• First Submitted: March 12, 2026
• First Posted: March 17, 2026
• Study Start: April 13, 2026
• Primary Completion: June 30, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: March 23, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF

Locations

ID (1)