Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis

NCT07475793 | Not Yet Recruiting

• 1 other identifier: 2026-12711-40401
• Study Type: interventional
• Target: 52
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this prospective randomized control trial is to provide continued pain relief, classically long-lasting 3 to12 months, and enhanced function in patients following: both gender; male and female, age group; \>50yr, healthy volunteers along with Radiographic diagnosis of knee OA with KL grade 3 and 4 in addition of Chronic knee pain ≥ 6 months and patients with ≥50% decrease in pain strength after diagnostic genicular nerve block. The main question it aims to answer is: Is ultrasound-guided genicular nerve RFA more efficient in lowering pain intensity at six months contrasted with fluoroscopic guided method in patients with chronic knee osteoarthritis? Researchers will compare Group A (Fluoroscopic) to Group B (Ultrasound) to see comparison in efficiency of ultrasound guided against fluoroscopic guided genicular nerves block for decrease in pain intensity and functional improvement.

Conditions

Chronic Knee Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Effectiveness of Block

  Block will be considered effective if decrease in pain score from baseline is \>50% at six months. And this will measure by using the 11-point Numeric Rating Scale (NRS) where 0 = no pain and 10 = worst imaginable pain.

  Post procedure 2 weeks, then follow up after 2, 4 and 6 months.

Secondary Outcomes (1)

• Functional Improvement after block

  6 months

Study Arms (2)

Group B

EXPERIMENTAL

Intervention group in which genicular nerves radiofrequency ablation will be done with the help ultrasound guidance.

Procedure: Ultrasound Guided

Group A

ACTIVE COMPARATOR

Control group in which genicular nerves radiofrequency ablation will be done with the help of fluoroscopic guidance.

Procedure: Fluoroscope Guided

Interventions

Ultrasound Guided PROCEDURE

Genicular nerves radiofrequency ablation will be done with the help of ultrasound guidance.

Group B

Fluoroscope Guided PROCEDURE

Control group in which genicular nerves radiofrequency ablation will be done with the help of fluoroscopic guidance.

Group A

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both gender patients of age more than 50 years.
• Radiographic diagnosis of knee OA with KL level 3 and 4.
• Chronic knee pain for more than 6 months
• Patients with more than 50% reduction in pain intensity after diagnostic genicular nerve block

You may not qualify if:

• Lack of consent
• surgery of knee
• Patient with BMI more than 40kg/m2
• Intra-articular steroid injection or hyaluronic acid in last 3 months
• Localized infection at procedure site or knee.
• Patient unable to communicate properly (Severe psychiatric illness, severe dementia and cognitive impairment).
• Patients have moderate to severe low back pain (NRS ≥5)

Sponsors & Collaborators

• Aga Khan University: lead

Study Officials

• Ali Sarfraz Siddiqui, MBBS-FCPS

  Aga Khan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ali Sarfraz Siddiqui, MBBS-FCPS

CONTACT

+92 021-38104397; sarfraz.siddiqui@aku.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 13, 2026
• First Posted: March 17, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): April 30, 2027
• Study Completion (Estimated): May 31, 2027
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share