Exergaming for Improving Upper Limb Functions in Parkinson's Disease

NCT07475741 | Recruiting DMC

• 1 other identifier: UHS/DPS-25/1158
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson's Disease commonly results in impaired hand dexterity, reducing a patient's ability to perform activities of daily living. While digital exergaming has been used to encourage physical activity and improve motor function, it often lacks real-world tactile engagement. Integrating physical objects into exergaming known as a phygital approach which may enhance sensorimotor learning and functional carryover. However, its impact on upper limb functional outcomes in PD remains underexplored. Objectives: To assess the effectiveness of exergaming with physical objects on functional outcomes of upper limb rehabilitation in individuals with Parkinson's Disease. Methodology: This randomized controlled pilot study will include 30 individuals with early-stage Parkinson's Disease, recruited through convenience sampling and randomly assigned to either a phygital exergaming group or a control group. Both groups will receive sessions over three monthd (3 sessions/week, 30 minutes each). The phygital group will perform task-based exergaming using both physical objects and digital prompts, while the control group will use digital prompts alone. Functional outcomes will be assessed using the Box and Block Test (BBT), at baseline (day 1) and post intervention 12 weeks. Statistical Analysis: Data will be analyzed using SPSS version 25. Descriptive statistics like gender, stages of diseases etc. will be summarized and described as bar charts and percentages. Within-group differences will be assessed using paired t-tests or Wilcoxon signed-rank tests based on data normality. Between-group comparisons will be conducted using independent t-tests or Mann-Whitney U tests. A p-value of less than 0.05 will be considered statistically significant.

Conditions

Parkinsons Disease (PD)

Keywords

Exergaming; Parkinson Disease; Physical Therapy; Upper Limb Rehabilitation

Outcome Measures

Primary Outcomes (1)

• Box and Block Test

  The Box and Block Test (BBT) is a 60-second, standardized, unilateral assessment measuring gross manual dexterity in individuals with Parkinson's Condition

  Baseline Measurements at day 1 will be taken prior to the interventions, and late Post-treatment after 12 weeks of intervention, another assessment will be taken. At followup visits, the consistency in the improvement will be assessed.

Study Arms (2)

Control Group (Conventional Physical Therapy Group)

ACTIVE COMPARATOR

It will act as control group. The participants in this control group will receive the 36 sessions (three sessions per week over 12 weeks), each lasting approximately 30 minutes).

Procedure: Conventional Physical Therapy

Phygital Group (Exergamig)

EXPERIMENTAL

The intervention group (phygital) will receive thirty six sessions (three sessions per week over twelve weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop.

Combination Product: Exergaming

Interventions

Exergaming COMBINATION_PRODUCT

The intervention group (phygital) will receive 36 sessions (three sessions per week over twelve weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop.

Also known as: Phygital Training

Phygital Group (Exergamig)

Conventional Physical Therapy PROCEDURE

Patients will receive routine physiotherapy treatment based on the impairments: Strength Training Flexibility and Mobility Balance and Coordination Gait and Functional Training Conentional Physical Therapy

Also known as: Strength Training, Flexibility and Mobility, Balance and Coordination, Gait and Functional Training, Conentional Physical Therapy

Control Group (Conventional Physical Therapy Group)

Eligibility Criteria

• Age: 45 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Early-stage Parkinson's Disease from I-III of Hoehn and Yahr scale
• Cognitinve Assessment MMSE \>= 24 Score
• Able to communicate and understand the commands
• Must be on regular use of Levodopa/carbidopa

You may not qualify if:

• Advanced stage IV or V
• Patients with severe cognitive deficits.
• History of suffering from other neurological or musculoskeletal conditions affecting hand use for the exercise
• Not taking any medicine for systemic illness

Sponsors & Collaborators

• University of Health Sciences Lahore: lead
• Punjab Institute of Neurosciences Lahore: collaborator

Study Sites (1)

Punjab institute of Neuroscience Lahore

Lahore, Punjab Province, 54000, Pakistan

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Interventions

Exergaming; Resistance Training; Pliability; Range of Motion, Articular; Gait

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Mechanical Phenomena; Physical Phenomena; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Walking; Locomotion

Study Officials

• Dr. Nadia Naseem, Ph.D.

  University of Health Sciences Lahore

  STUDY CHAIR

Central Study Contacts

Hafiz Muddassir Riaz, Ph.D Scholar

CONTACT

+92345-6627409; muddassir.riaz@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: March 5, 2026
• First Posted: March 16, 2026
• Study Start: February 20, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)