Effect of Mandibular Drilling Speed on Implant Stability and Osteogenic Potential: A Randomized Clinical Trial
Impact of Mandibular Biological Drilling Speeds on Implant Stability and Osteogenic Potential of Autogenous Bone Particles: A Randomized Clinical Trial
1 other identifier
interventional
36
0 countries
N/A
Brief Summary
This randomized clinical trial aims to evaluate the effect of different low-speed biological drilling protocols on implant stability and the osteogenic potential of autogenous bone particles collected during implant osteotomy. Patients requiring single dental implant placement in the mandible will be randomly assigned to different drilling speed protocols without irrigation. Implant stability will be measured clinically, while collected bone particles will be analyzed for osteogenic markers. The study aims to determine whether biological drilling improves implant stability and preserves the regenerative potential of autogenous bone.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2026
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 11, 2026
CompletedStudy Start
First participant enrolled
March 15, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 15, 2026
CompletedFirst Posted
Study publicly available on registry
March 16, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2027
ExpectedMarch 16, 2026
March 1, 2026
Same day
March 11, 2026
March 11, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Implant Stability
Implant stability will be measured immediately after implant placement and 3 months postoperatively, using resonance frequency analysis (RFA). Implant stability will be recorded as an Implant Stability Quotient (ISQ) value to evaluate the mechanical stability of the implant in relation to the drilling speed used during osteotomy.
At time of insertion and 3 months postoperatively.
Secondary Outcomes (1)
Osteogenic Potential of Autogenous Bone Particles
Immediately after bone particle collection and subsequent laboratory analysis.
Study Arms (3)
50 rpm Biological Drilling
EXPERIMENTALImplant osteotomy will be performed using low-speed biological drilling at 50 rpm without irrigation. Bone particles produced during drilling will be collected for evaluation of osteogenic potential.
150 rpm Biological Drilling
EXPERIMENTALImplant osteotomy will be performed using biological drilling at 150 rpm without irrigation. Autogenous bone particles generated during drilling will be collected and analyzed for osteogenic potential.
300 rpm Biological Drilling
EXPERIMENTALImplant osteotomy will be performed using biological drilling at 300 rpm without irrigation with collection of autogenous bone particles for laboratory analysis.
Interventions
Implant osteotomy will be performed using low-speed biological drilling at 50 rpm without irrigation. Bone particles produced during drilling will be collected for evaluation of osteogenic potential.
Implant osteotomy will be performed using biological drilling at 150 rpm without irrigation. Autogenous bone particles generated during drilling will be collected and analyzed for osteogenic potential.
Implant osteotomy will be performed using biological drilling at 300 rpm without irrigation with collection of autogenous bone particles for laboratory analysis.
Eligibility Criteria
You may qualify if:
- Adult patients requiring single dental implant placement in the mandible
- Adequate bone volume for implant placement without need for bone grafting
- Good general health
- Ability to provide informed consent
You may not qualify if:
- Systemic diseases affecting bone metabolism or healing
- History of radiotherapy in the head and neck region
- Uncontrolled diabetes mellitus
- Active periodontal disease
- Heavy smoking
- Pregnancy or lactation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Related Publications (1)
Camacho-Alonso F, Mercado-Diaz AM, Rivas-Ballester R, Bernabeu-Mira JC, Penarrocha-Oltra D, Del Rosario Tudela-Mulero M. Randomized split-mouth clinical trial comparing osteoblastic activity and osteogenic potential of autogenous particle harvesting during implant surgery without irrigation and with irrigation. Clin Implant Dent Relat Res. 2024 Aug;26(4):795-808. doi: 10.1111/cid.13355. Epub 2024 Jun 23.
PMID: 38922797BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Masking Details
- The investigator responsible for laboratory analysis of bone particle samples and outcome assessment will be blinded to the drilling speed group allocation.
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
March 11, 2026
First Posted
March 16, 2026
Study Start
March 15, 2026
Primary Completion
March 15, 2026
Study Completion (Estimated)
April 1, 2027
Last Updated
March 16, 2026
Record last verified: 2026-03