From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma

NCT07474506 | Not Yet Recruiting

• 2 other identifiers: 130301032026Superhumans war trauma center
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.

Conditions

Pain Management; Perioperative Analgesia; War-Related Injuries

Keywords

acute pain; pain managment; analgesia; war related trauma

Outcome Measures

Primary Outcomes (1)

• Pain intensity measured by Numeric Rating Scale (NRS 0-10) during the first 72 hours after initiation of analgesic treatment.

  Pain scores will be recorded: at rest during movement during wound care or dressing changes.

  Pain intensity will be assessed at 6, 12, 24, 48, and 72 hours after initiation of analgesia.

Secondary Outcomes (1)

• Total opioid consumption during first 72 hours, expressed as morphine milligram equivalents (MME).

  Cumulative opioid consumption during the first 72 hours after initiation of analgesic therapy.

Study Arms (2)

Group A - Continuous Regional Anaesthesia (CRA)

atients receiving continuous peripheral nerve blockade using perineural catheters with continuous or intermittent infusion of local anesthetic. Possible catheter locations include: femoral nerve sciatic nerve popliteal sciatic nerve adductor canal fascia iliaca combined catheter techniques

Group B - Standard Analgesia (Control Group)

Patients receiving standard pain management without continuous regional anaesthesia, including: systemic multimodal analgesia (opioids, NSAIDs, paracetamol, adjuvant medications) single-shot regional nerve block (if used) epidural analgesia where clinically indicated Analgesic strategy will follow standard clinical practice at each participating center.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include adult patients with war-related lower limb trauma who are admitted to participating trauma and rehabilitation centers and require inpatient treatment. Injuries may include blast injuries, gunshot wounds, shrapnel injuries, and other combat-related mechanisms affecting the lower extremities. Eligible patients will be those receiving pain management during hospitalization, including continuous regional anaesthesia with peripheral nerve catheters or standard multimodal analgesia. The study will include patients treated at participating institutions such as Vinnytsia National Pirogov Memorial Medical University and the Superhumans Center.

You may qualify if:

• age ≥18 years
• war-related lower limb trauma
• hospital admission requiring surgical treatment or wound management
• documented pain assessment during hospitalization
• availability of analgesic treatment data
• informed consent where required

You may not qualify if:

• age \<18 years
• isolated upper limb trauma
• missing key pain outcome data
• contraindication to regional anaesthesia prior to treatment
• refusal to participate (for prospective component)

Sponsors & Collaborators

• Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans): lead

Study Sites (1)

Superhumans War Trauma Center

Lviv, Ukraine

Location

Related Publications (1)

• DOI: 10.1016/j.ejvs.2014.07.002

  BACKGROUND

MeSH Terms

Conditions

Agnosia; War-Related Injuries; Acute Pain

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Wounds and Injuries; Pain

Central Study Contacts

Dmytro Dmitriy Dmytriiev, PhD.Professor

CONTACT

+380674309449; d.dmytriiev@superhumans.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Weeks
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 11, 2026
• First Posted: March 16, 2026
• Study Start: March 15, 2026
• Primary Completion: June 15, 2026
• Study Completion: June 15, 2026
• Last Updated: March 17, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

UA (1)