NCT07474441

Brief Summary

This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute coronary syndrome.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
139

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 2017

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2017

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2021

Completed
4.2 years until next milestone

First Submitted

Initial submission to the registry

March 11, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 16, 2026

Completed
Last Updated

March 16, 2026

Status Verified

March 1, 2026

Enrollment Period

5 years

First QC Date

March 11, 2026

Last Update Submit

March 11, 2026

Conditions

CKDACS (Acute Coronary Syndrome)Coronary Angiography (CAG)

Outcome Measures

Primary Outcomes (1)

  • Renal replacement therapy initiation

    Renal replacement therapy initiation

    Until 31 December 2021

Secondary Outcomes (1)

  • All-cause mortality

    Until 31 Dec 2021

Study Arms (3)

Early coronary angiography

Recieve coronary angiography within 24 hours of admission

Procedure: coronary angiography

Delayed coronary angiography

Recieve coronary angiography later than 24 hours of admission

Procedure: coronary angiography

Conservative management

Medical management without coronary angiography

Interventions

coronary angiographyPROCEDURE

Standard coronary angiography

Also known as: medication
Delayed coronary angiographyEarly coronary angiography

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with pre-dialysis CKD stage 4-5 with acute coronary syndrome

You may qualify if:

  • Advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m²
  • Diagnosis with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital

You may not qualify if:

  • Received maintenance dialysis or kidney transplantation before admission
  • Cardiogenic shock or cardiac arrest
  • Prior PCI or CABG within 12 months
  • Recently diagnosed with ACS within 2 months
  • Had a limited life expectancy due to non-cardiovascular disease
  • Pregnant.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Acute Coronary Syndrome

Interventions

Dosage Forms

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular Diseases

Intervention Hierarchy (Ancestors)

Pharmaceutical PreparationsTechnology, PharmaceuticalInvestigative Techniques

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr.

Study Record Dates

First Submitted

March 11, 2026

First Posted

March 16, 2026

Study Start

January 1, 2017

Primary Completion

December 31, 2021

Study Completion

December 31, 2021

Last Updated

March 16, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

All data generated or analyzed during this study are included in this article.