NCT07474220

Brief Summary

This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation with inflammatory markers and choline metabolic byproducts.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
180

participants targeted

Target at P50-P75 for all trials

Timeline
5mo left

Started Jun 2026

Shorter than P25 for all trials

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress21%
Jun 2026Dec 2026

First Submitted

Initial submission to the registry

March 11, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 16, 2026

Completed
4 months until next milestone

Study Start

First participant enrolled

June 29, 2026

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

July 6, 2026

Status Verified

March 1, 2026

Enrollment Period

6 months

First QC Date

March 11, 2026

Last Update Submit

July 1, 2026

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic obstructive pulmonary diseaseMitochondrial choline transportSLC25A48Inflammatory markersCholine metabolism

Outcome Measures

Primary Outcomes (1)

  • expression of SLC25A48

    the expression level of SLC25A48 in mitochondria isolated from peripheral blood mononuclear cells

    one day

Study Arms (2)

Case group

Pre-COPD or COPD stages I-IV as per the 2023 GOLD guidelines

Control group

healthy controls

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patient of hospital

You may qualify if:

  • pre-COPD or COPD stages I-IV as per the 2023 GOLD guidelines (case group)
  • healthy individuals without chronic diseases or major medical conditions

You may not qualify if:

  • diagnosed with neuromuscular diseases
  • experienced respiratory disease exacerbation requiring emergency care or hospitalization in the past three months
  • assessed by a physician to have severe malnutrition or a significantly low BMI
  • continuously taking folic acid supplements
  • willing to receive or have already received self-paid nutrition clinic services at this hospital

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Cardinal Tien Hospital

New Taipei City, 23148, Taiwan

NOT YET RECRUITING

Fu Jen Catholic University Hospital, Fu Jen Catholic University

New Taipei City, 24352, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Peripheral venous blood samples will be collected. Plasma, isolated peripheral blood mononuclear cells will be retained.

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Ke-Yun Chao, PhD

    Fu Jen Catholic University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ke-Yun Chao, PhD

CONTACT

+886-905-301-879ck_qq@hotmail.com

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

March 11, 2026

First Posted

March 16, 2026

Study Start

June 29, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

July 6, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

TW(2)