NCT07474220

Recruiting

Expression of SLC25A48 in Chronic Obstructive Pulmonary Dise...

Fu Jen Catholic University Source

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Other study identifiers

Sponsor study identifier

FJUH114470

Study Type

observational

Estimated enrollment

180

Locations

1 country

Sites

2

Timeline

Study Start

June 29, 2026

Actual (reported)

Primary Completion

December 31, 2026

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

December 31, 2026

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Brief Summary

This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation with inflammatory markers and choline metabolic byproducts.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: recruiting
Estimated enrollment: 180 participants
Study completion date: December 31, 2026
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Listed locations: 1 countries · 2 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
March 11, 2026
Actual (reported)
First Posted
March 16, 2026
Actual (reported)
Study Start
June 29, 2026
Actual (reported)
Primary Completion
December 31, 2026
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2026
Estimated
Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated: July 6, 2026
Status Verified: March 2026
Last Update Submitted: July 1, 2026

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic obstructive pulmonary diseaseMitochondrial choline transportSLC25A48Inflammatory markersCholine metabolism

Outcome Measures

Primary Outcomes (1)

expression of SLC25A48
the expression level of SLC25A48 in mitochondria isolated from peripheral blood mononuclear cells
one day

Study Arms (2)

Case group

Pre-COPD or COPD stages I-IV as per the 2023 GOLD guidelines

Control group

healthy controls

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

patient of hospital

You may qualify if:

pre-COPD or COPD stages I-IV as per the 2023 GOLD guidelines (case group)

Sponsors & Collaborators

Fu Jen Catholic University
Otherlead

Study Sites (2)

Cardinal Tien Hospital

New Taipei City, 23148, Taiwan

NOT_YET_RECRUITING

Ke-Yun Chao, PhDCONTACT+886-905-301-879 ck_qq@hotmail.con

Fu Jen Catholic University Hospital, Fu Jen Catholic University

New Taipei City, 24352, Taiwan

RECRUITING

Ke-Yun Chao, PhDCONTACT+886-905-301-879

Biospecimen

Retention: SAMPLES WITHOUT DNA

Peripheral venous blood samples will be collected. Plasma, isolated peripheral blood mononuclear cells will be retained.

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

Ke-Yun Chao, PhD
Fu Jen Catholic University
PRINCIPAL INVESTIGATOR

Central Study Contacts

Ke-Yun Chao, PhD

CONTACT

+886-905-301-879 ck_qq@hotmail.com

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Assistant Professor

Study Record Dates

First Submitted

March 11, 2026

First Posted

March 16, 2026

Study Start

June 29, 2026

Actual (reported)

Primary Completion

December 31, 2026

Estimated

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healthy individuals without chronic diseases or major medical conditions

You may not qualify if:

diagnosed with neuromuscular diseases
experienced respiratory disease exacerbation requiring emergency care or hospitalization in the past three months
assessed by a physician to have severe malnutrition or a significantly low BMI
continuously taking folic acid supplements
willing to receive or have already received self-paid nutrition clinic services at this hospital

Contact the study team to confirm eligibility.

ck_qq@hotmail.con

Planned date reported by the registry; this milestone is not confirmed as achieved.

Study Completion

December 31, 2026

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Last Updated

July 6, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT07474220
Data provider: ClinicalTrials.gov
Source updated: 2026-07-06
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:24:10 UTC

Locations

TW(2)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

Case group

Control group

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations