Pneumoperitoneum Duration and Bicarbonate Changes in Laparoscopic Hernia Surgery

NCT07473583 | Recruiting

• 1 other identifier: HASEKI-305-2025
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn how the length of pneumoperitoneum during laparoscopic inguinal hernia surgery may affect changes in blood bicarbonate levels. Pneumoperitoneum is the use of carbon dioxide gas to create space inside the abdomen during laparoscopic surgery. The main question this study aims to answer is whether a longer pneumoperitoneum time is associated with changes in blood bicarbonate levels after surgery. Participants are adults undergoing laparoscopic inguinal hernia repair as part of their routine medical care. Researchers will measure blood gas values, including bicarbonate levels, before surgery and again two hours after surgery. The change in bicarbonate levels will be compared with the duration of pneumoperitoneum during the operation. The results of this study may help improve the understanding of metabolic changes that occur during laparoscopic surgery.

Conditions

Hernia, Inguinal; Inguinal Hernia

Keywords

Pneumoperitoneum; Laparoscopic Inguinal Hernia Repair; Serum Bicarbonate; Blood Gas Analysis; TAPP Technique

Outcome Measures

Primary Outcomes (1)

• Change in Serum Bicarbonate Level

  Difference between preoperative and postoperative second-hour serum bicarbonate levels measured by blood gas analysis in patients undergoing laparoscopic inguinal hernia repair. Unit of Measure: mmol/L

  Preoperative to postoperative 2 hours

Secondary Outcomes (4)

• Postoperative Pain Score

  Within 24 hours after surgery

• Change in Arterial Blood pH

  Preoperative to postoperative 2 hours

• Early Postoperative Complications

  Within 24 hours

• Change in Arterial Partial Pressure of Carbon Dioxide

  Preoperative to postoperative 2 hours

Study Arms (1)

Laparoscopic Inguinal Hernia Patients

Adult patients undergoing laparoscopic inguinal hernia repair (TAPP). Pneumoperitoneum duration and perioperative serum bicarbonate changes will be analyzed using blood gas measurements obtained preoperatively and at the second postoperative hour.

Procedure: Laparoscopic Inguinal Hernia Repair (TAPP)

Interventions

Laparoscopic Inguinal Hernia Repair (TAPP) PROCEDURE

Standard laparoscopic inguinal hernia repair performed using the transabdominal preperitoneal (TAPP) technique as part of routine clinical care. Pneumoperitoneum duration during the procedure will be recorded for analysis.

Laparoscopic Inguinal Hernia Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing laparoscopic inguinal hernia repair (TAPP) at Haseki Training and Research Hospital will be included. Perioperative pneumoperitoneum duration and serum bicarbonate changes will be analyzed using blood gas measurements obtained preoperatively and at the second postoperative hour.

You may qualify if:

• Age ≥18 years
• Patients undergoing laparoscopic inguinal hernia repair using the TAPP technique
• Ability to provide informed consent

You may not qualify if:

• Pregnancy
• Severe cardiovascular disease
• Renal insufficiency
• Patients requiring additional intra-abdominal surgical procedures
• Strangulated inguinal hernia requiring bowel resection

Sponsors & Collaborators

• Haseki Training and Research Hospital: lead

Study Sites (1)

Haseki Training and Research Hospital

Istanbul, 34265, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Hernia, Inguinal; Pneumoperitoneum

Interventions

tetra-4-amidinophenoxypropane

Condition Hierarchy (Ancestors)

Hernia, Abdominal; Hernia; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Peritoneal Diseases; Digestive System Diseases

Study Officials

• Muzaffer Akinci, MD

  Haseki Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Osman Sibic, MD

CONTACT

+90 534 617 72 53; osmansibic@gmail.com

Bahar Canbay Torun, MD

CONTACT

+90 505 389 0489; baharcanbay@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 6, 2026
• First Posted: March 16, 2026
• Study Start: March 10, 2026
• Primary Completion: April 1, 2026
• Study Completion: May 1, 2026
• Last Updated: March 16, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)